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Myosin-dependent cell-cell communication controls synchronicity of division in acute and chronic stages of Toxoplasma gondii

Author

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  • Karine Frénal

    (CMU, University of Geneva)

  • Damien Jacot

    (CMU, University of Geneva)

  • Pierre-Mehdi Hammoudi

    (CMU, University of Geneva)

  • Arnault Graindorge

    (CMU, University of Geneva
    Present address: Laboratoire de Biologie Cellulaire et Moléculaire, Faculté des Sciences Pharmaceutiques et Biologiques, 15 Avenue Charles Flahault, 34093 Montpellier Cedex 5, France)

  • Bohumil Maco

    (CMU, University of Geneva)

  • Dominique Soldati-Favre

    (CMU, University of Geneva)

Abstract

The obligate intracellular parasite Toxoplasma gondii possesses a repertoire of 11 myosins. Three class XIV motors participate in motility, invasion and egress, whereas the class XXII myosin F is implicated in organelle positioning and inheritance of the apicoplast. Here we provide evidence that TgUNC acts as a chaperone dedicated to the folding, assembly and function of all Toxoplasma myosins. The conditional ablation of TgUNC recapitulates the phenome of the known myosins and uncovers two functions in parasite basal complex constriction and synchronized division within the parasitophorous vacuole. We identify myosin J and centrin 2 as essential for the constriction. We demonstrate the existence of an intravacuolar cell–cell communication ensuring synchronized division, a process dependent on myosin I. This connectivity contributes to the delayed death phenotype resulting from loss of the apicoplast. Cell–cell communication is lost in activated macrophages and during bradyzoite differentiation resulting in asynchronized, slow division in the cysts.

Suggested Citation

  • Karine Frénal & Damien Jacot & Pierre-Mehdi Hammoudi & Arnault Graindorge & Bohumil Maco & Dominique Soldati-Favre, 2017. "Myosin-dependent cell-cell communication controls synchronicity of division in acute and chronic stages of Toxoplasma gondii," Nature Communications, Nature, vol. 8(1), pages 1-18, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15710
    DOI: 10.1038/ncomms15710
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    Cited by:

    1. Klemens Engelberg & Tyler Bechtel & Cynthia Michaud & Eranthie Weerapana & Marc-Jan Gubbels, 2022. "Proteomic characterization of the Toxoplasma gondii cytokinesis machinery portrays an expanded hierarchy of its assembly and function," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Alexander A. Morano & Rachel M. Rudlaff & Jeffrey D. Dvorin, 2023. "A PPP-type pseudophosphatase is required for the maintenance of basal complex integrity in Plasmodium falciparum," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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