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A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses

Author

Listed:
  • Yufeng Yu

    (Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University)

  • Yong-Qiang Deng

    (State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology)

  • Peng Zou

    (Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University)

  • Qian Wang

    (Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University)

  • Yanyan Dai

    (Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University)

  • Fei Yu

    (Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University)

  • Lanying Du

    (Lindsley F. Kimball Research Institute, New York Blood Center)

  • Na-Na Zhang

    (State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology)

  • Min Tian

    (Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University)

  • Jia-Nan Hao

    (State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology)

  • Yu Meng

    (Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University)

  • Yuan Li

    (Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University)

  • Xiaohui Zhou

    (Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University)

  • Jasper Fuk-Woo Chan

    (State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong)

  • Kwok-Yung Yuen

    (State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong)

  • Cheng-Feng Qin

    (State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology)

  • Shibo Jiang

    (Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University
    Lindsley F. Kimball Research Institute, New York Blood Center)

  • Lu Lu

    (Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University)

Abstract

Zika virus (ZIKV), a re-emerging flavivirus associated with neurological disorders, has spread rapidly to more than 70 countries and territories. However, no specific vaccines or antiviral drugs are currently available to prevent or treat ZIKV infection. Here we report that a synthetic peptide derived from the stem region of ZIKV envelope protein, designated Z2, potently inhibits infection of ZIKV and other flaviviruses in vitro. We show that Z2 interacts with ZIKV surface protein and disrupts the integrity of the viral membrane. Z2 can penetrate the placental barrier to enter fetal tissues and is safe for use in pregnant mice. Intraperitoneal administration of Z2 inhibits vertical transmission of ZIKV in pregnant C57BL/6 mice and protects type I or type I/II interferon receptor-deficient mice against lethal ZIKV challenge. Thus, Z2 has potential to be further developed as an antiviral treatment against ZIKV infection in high-risk populations, particularly pregnant women.

Suggested Citation

  • Yufeng Yu & Yong-Qiang Deng & Peng Zou & Qian Wang & Yanyan Dai & Fei Yu & Lanying Du & Na-Na Zhang & Min Tian & Jia-Nan Hao & Yu Meng & Yuan Li & Xiaohui Zhou & Jasper Fuk-Woo Chan & Kwok-Yung Yuen &, 2017. "A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses," Nature Communications, Nature, vol. 8(1), pages 1-12, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15672
    DOI: 10.1038/ncomms15672
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    Cited by:

    1. Wenqian Hu & Han Gao & Chunlai Cui & Lihua Wang & Yiguan Wang & Yifei Li & Fang Li & Yitong Zheng & Tianyu Xia & Sibao Wang, 2025. "Harnessing engineered symbionts to combat concurrent malaria and arboviruses transmission," Nature Communications, Nature, vol. 16(1), pages 1-13, December.

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