IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v8y2017i1d10.1038_ncomms15594.html
   My bibliography  Save this article

Magnetic forces enable controlled drug delivery by disrupting endothelial cell-cell junctions

Author

Listed:
  • Yongzhi Qiu

    (Georgia Institute of Technology and Emory University
    Aflac Cancer and Blood Disorders Center of Children’s Healthcare of Atlanta, Emory University School of Medicine
    Winship Cancer Institute of Emory University)

  • Sheng Tong

    (Rice University)

  • Linlin Zhang

    (Rice University)

  • Yumiko Sakurai

    (Georgia Institute of Technology and Emory University
    Aflac Cancer and Blood Disorders Center of Children’s Healthcare of Atlanta, Emory University School of Medicine
    Winship Cancer Institute of Emory University)

  • David R. Myers

    (Georgia Institute of Technology and Emory University
    Aflac Cancer and Blood Disorders Center of Children’s Healthcare of Atlanta, Emory University School of Medicine
    Winship Cancer Institute of Emory University)

  • Lin Hong

    (Rice University)

  • Wilbur A. Lam

    (Georgia Institute of Technology and Emory University
    Aflac Cancer and Blood Disorders Center of Children’s Healthcare of Atlanta, Emory University School of Medicine
    Winship Cancer Institute of Emory University)

  • Gang Bao

    (Rice University)

Abstract

The vascular endothelium presents a major transport barrier to drug delivery by only allowing selective extravasation of solutes and small molecules. Therefore, enhancing drug transport across the endothelial barrier has to rely on leaky vessels arising from disease states such as pathological angiogenesis and inflammatory response. Here we show that the permeability of vascular endothelium can be increased using an external magnetic field to temporarily disrupt endothelial adherens junctions through internalized iron oxide nanoparticles, activating the paracellular transport pathway and facilitating the local extravasation of circulating substances. This approach provides a physically controlled drug delivery method harnessing the biology of endothelial adherens junction and opens a new avenue for drug delivery in a broad range of biomedical research and therapeutic applications.

Suggested Citation

  • Yongzhi Qiu & Sheng Tong & Linlin Zhang & Yumiko Sakurai & David R. Myers & Lin Hong & Wilbur A. Lam & Gang Bao, 2017. "Magnetic forces enable controlled drug delivery by disrupting endothelial cell-cell junctions," Nature Communications, Nature, vol. 8(1), pages 1-10, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15594
    DOI: 10.1038/ncomms15594
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms15594
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms15594?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15594. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.