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Impact of fat mass and distribution on lipid turnover in human adipose tissue

Author

Listed:
  • Kirsty L. Spalding

    (Karolinska Institutet
    Metabolism Unit and KI/AZ Integrated Cardio Metabolic Center, Karolinska University Hospital, Karolinska Institutet)

  • Samuel Bernard

    (Institut Camille Jordan, University of Lyon)

  • Erik Näslund

    (Danderyd Hospital, Karolinska Institutet)

  • Mehran Salehpour

    (Ion Physics, Uppsala University)

  • Göran Possnert

    (Ion Physics, Uppsala University)

  • Lena Appelsved

    (Karolinska Institutet)

  • Keng-Yeh Fu

    (Karolinska Institutet)

  • Kanar Alkass

    (Karolinska Institutet)

  • Henrik Druid

    (Karolinska Institutet
    The National Board of Forensic Medicine)

  • Anders Thorell

    (Danderyd Hospital, Karolinska Institutet
    Ersta Hospital, Karolinska Institutet)

  • Mikael Rydén

    (Karolinska University Hospital, Karolinska Institutet)

  • Peter Arner

    (Karolinska University Hospital, Karolinska Institutet)

Abstract

Differences in white adipose tissue (WAT) lipid turnover between the visceral (vWAT) and subcutaneous (sWAT) depots may cause metabolic complications in obesity. Here we compare triglyceride age and, thereby, triglyceride turnover in vWAT and sWAT biopsies from 346 individuals and find that subcutaneous triglyceride age and storage capacity are increased in overweight or obese individuals. Visceral triglyceride age is only increased in excessively obese individuals and associated with a lower lipid removal capacity. Thus, although triglyceride storage capacity in sWAT is higher than in vWAT, the former plateaus at substantially lower levels of excess WAT mass than vWAT. In individuals with central or visceral obesity, lipid turnover is selectively increased in vWAT. Obese individuals classified as ‘metabolically unhealthy’ (according to ATPIII criteria) who have small subcutaneous adipocytes exhibit reduced triglyceride turnover. We conclude that excess WAT results in depot-specific differences in lipid turnover and increased turnover in vWAT and/or decreased turnover in sWAT may result in metabolic complications of overweight or obesity.

Suggested Citation

  • Kirsty L. Spalding & Samuel Bernard & Erik Näslund & Mehran Salehpour & Göran Possnert & Lena Appelsved & Keng-Yeh Fu & Kanar Alkass & Henrik Druid & Anders Thorell & Mikael Rydén & Peter Arner, 2017. "Impact of fat mass and distribution on lipid turnover in human adipose tissue," Nature Communications, Nature, vol. 8(1), pages 1-9, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15253
    DOI: 10.1038/ncomms15253
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