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A peripheral epigenetic signature of immune system genes is linked to neocortical thickness and memory

Author

Listed:
  • Virginie Freytag

    (University of Basel
    Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel)

  • Tania Carrillo-Roa

    (Max Planck Institute of Psychiatry)

  • Annette Milnik

    (University of Basel
    Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
    Psychiatric University Clinics, University of Basel)

  • Philipp G. Sämann

    (Max Planck Institute of Psychiatry)

  • Vanja Vukojevic

    (University of Basel
    Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
    Life Sciences Training Facility, University of Basel)

  • David Coynel

    (Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
    University of Basel)

  • Philippe Demougin

    (University of Basel
    Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
    Life Sciences Training Facility, University of Basel)

  • Tobias Egli

    (University of Basel
    Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel)

  • Leo Gschwind

    (Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
    University of Basel)

  • Frank Jessen

    (German Center for Neurodegenerative Diseases (DZNE)
    University of Cologne, Medical Faculty)

  • Eva Loos

    (Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
    University of Basel)

  • Wolfgang Maier

    (German Center for Neurodegenerative Diseases (DZNE)
    University of Bonn)

  • Steffi G. Riedel-Heller

    (Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig)

  • Martin Scherer

    (Center for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf)

  • Christian Vogler

    (University of Basel
    Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
    Psychiatric University Clinics, University of Basel)

  • Michael Wagner

    (German Center for Neurodegenerative Diseases (DZNE)
    University of Bonn)

  • Elisabeth B. Binder

    (Max Planck Institute of Psychiatry
    Emory University School of Medicine)

  • Dominique J. -F. de Quervain

    (Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
    Psychiatric University Clinics, University of Basel
    University of Basel)

  • Andreas Papassotiropoulos

    (University of Basel
    Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
    Psychiatric University Clinics, University of Basel
    Life Sciences Training Facility, University of Basel)

Abstract

Increasing age is tightly linked to decreased thickness of the human neocortex. The biological mechanisms that mediate this effect are hitherto unknown. The DNA methylome, as part of the epigenome, contributes significantly to age-related phenotypic changes. Here, we identify an epigenetic signature that is associated with cortical thickness (P=3.86 × 10−8) and memory performance in 533 healthy young adults. The epigenetic effect on cortical thickness was replicated in a sample comprising 596 participants with major depressive disorder and healthy controls. The epigenetic signature mediates partially the effect of age on cortical thickness (P

Suggested Citation

  • Virginie Freytag & Tania Carrillo-Roa & Annette Milnik & Philipp G. Sämann & Vanja Vukojevic & David Coynel & Philippe Demougin & Tobias Egli & Leo Gschwind & Frank Jessen & Eva Loos & Wolfgang Maier , 2017. "A peripheral epigenetic signature of immune system genes is linked to neocortical thickness and memory," Nature Communications, Nature, vol. 8(1), pages 1-12, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15193
    DOI: 10.1038/ncomms15193
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