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Light-sensing via hydrogen peroxide and a peroxiredoxin

Author

Listed:
  • Kristofer Bodvard

    (University of Gothenburg
    Chalmers University of Technology)

  • Ken Peeters

    (University of Gothenburg)

  • Friederike Roger

    (University of Gothenburg)

  • Natalie Romanov

    (Mass Spectrometry Facility, Max F. Perutz Laboratories, University of Vienna
    Present address: Department of Structural and Computational Biology, EMBL, Meyerhofstrasse 1, 691 17 Heidelberg, Germany)

  • Aeid Igbaria

    (Oxidative Stress and Cancer, SBIGEM, iBiTec-S, FRE3377 CEA-CNRS-Université Paris-Sud)

  • Niek Welkenhuysen

    (University of Gothenburg
    Hohmann Lab, Chalmers University of Technology)

  • Gaël Palais

    (Oxidative Stress and Cancer, SBIGEM, iBiTec-S, FRE3377 CEA-CNRS-Université Paris-Sud)

  • Wolfgang Reiter

    (Max F. Perutz Laboratories, University of Vienna)

  • Michel B. Toledano

    (Oxidative Stress and Cancer, SBIGEM, iBiTec-S, FRE3377 CEA-CNRS-Université Paris-Sud)

  • Mikael Käll

    (Chalmers University of Technology)

  • Mikael Molin

    (University of Gothenburg)

Abstract

Yeast lacks dedicated photoreceptors; however, blue light still causes pronounced oscillations of the transcription factor Msn2 into and out of the nucleus. Here we show that this poorly understood phenomenon is initiated by a peroxisomal oxidase, which converts light into a hydrogen peroxide (H2O2) signal that is sensed by the peroxiredoxin Tsa1 and transduced to thioredoxin, to counteract PKA-dependent Msn2 phosphorylation. Upon H2O2, the nuclear retention of PKA catalytic subunits, which contributes to delayed Msn2 nuclear concentration, is antagonized in a Tsa1-dependent manner. Conversely, peroxiredoxin hyperoxidation interrupts the H2O2 signal and drives Msn2 oscillations by superimposing on PKA feedback regulation. Our data identify a mechanism by which light could be sensed in all cells lacking dedicated photoreceptors. In particular, the use of H2O2 as a second messenger in signalling is common to Msn2 oscillations and to light-induced entrainment of circadian rhythms and suggests conserved roles for peroxiredoxins in endogenous rhythms.

Suggested Citation

  • Kristofer Bodvard & Ken Peeters & Friederike Roger & Natalie Romanov & Aeid Igbaria & Niek Welkenhuysen & Gaël Palais & Wolfgang Reiter & Michel B. Toledano & Mikael Käll & Mikael Molin, 2017. "Light-sensing via hydrogen peroxide and a peroxiredoxin," Nature Communications, Nature, vol. 8(1), pages 1-11, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14791
    DOI: 10.1038/ncomms14791
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