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Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors

Author

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  • Bart C. Jongbloets

    (Brain Center Rudolf Magnus, University Medical Center Utrecht
    Present address: Vollum Institute, Oregon Health & Science University, Portland, Oregon 97239, USA)

  • Suzanne Lemstra

    (Brain Center Rudolf Magnus, University Medical Center Utrecht)

  • Roberta Schellino

    (University of Torino)

  • Mark H. Broekhoven

    (Brain Center Rudolf Magnus, University Medical Center Utrecht)

  • Jyoti Parkash

    (Centre for Animal Sciences, School of Basic and Applied Sciences, Central University Punjab)

  • Anita J. C. G. M. Hellemons

    (Brain Center Rudolf Magnus, University Medical Center Utrecht)

  • Tianyi Mao

    (Vollum Institute, Oregon Health & Science University)

  • Paolo Giacobini

    (Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre, U1172
    University of Lille)

  • Henriette van Praag

    (Neuroplasticity and Behavior Unit, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health)

  • Silvia De Marchis

    (University of Torino)

  • Geert M. J. Ramakers

    (Brain Center Rudolf Magnus, University Medical Center Utrecht)

  • R. Jeroen Pasterkamp

    (Brain Center Rudolf Magnus, University Medical Center Utrecht)

Abstract

The guidance protein Semaphorin7A (Sema7A) is required for the proper development of the immune and nervous systems. Despite strong expression in the mature brain, the role of Sema7A in the adult remains poorly defined. Here we show that Sema7A utilizes different cell surface receptors to control the proliferation and differentiation of neural progenitors in the adult hippocampal dentate gyrus (DG), one of the select regions of the mature brain where neurogenesis occurs. PlexinC1 is selectively expressed in early neural progenitors in the adult mouse DG and mediates the inhibitory effects of Sema7A on progenitor proliferation. Subsequently, during differentiation of adult-born DG granule cells, Sema7A promotes dendrite growth, complexity and spine development through β1-subunit-containing integrin receptors. Our data identify Sema7A as a key regulator of adult hippocampal neurogenesis, providing an example of how differential receptor usage spatiotemporally controls and diversifies the effects of guidance cues in the adult brain.

Suggested Citation

  • Bart C. Jongbloets & Suzanne Lemstra & Roberta Schellino & Mark H. Broekhoven & Jyoti Parkash & Anita J. C. G. M. Hellemons & Tianyi Mao & Paolo Giacobini & Henriette van Praag & Silvia De Marchis & G, 2017. "Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors," Nature Communications, Nature, vol. 8(1), pages 1-17, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14666
    DOI: 10.1038/ncomms14666
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