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Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential

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  • Evan Bardot

    (Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai
    Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai
    Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai)

  • Damelys Calderon

    (Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai
    Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai
    Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai)

  • Francis Santoriello

    (Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai
    Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai
    Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai)

  • Songyan Han

    (Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai
    Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai)

  • Kakit Cheung

    (Icahn School of Medicine at Mount Sinai)

  • Bharati Jadhav

    (Icahn School of Medicine at Mount Sinai)

  • Ingo Burtscher

    (Institute of Diabetes and Regeneration Research at the Helmholtz Zentrum München, German Center for Diabetes Research (DZD))

  • Stanley Artap

    (Cardiovascular Institute, University of Pennsylvania)

  • Rajan Jain

    (Cardiovascular Institute, University of Pennsylvania)

  • Jonathan Epstein

    (Cardiovascular Institute, University of Pennsylvania)

  • Heiko Lickert

    (Institute of Diabetes and Regeneration Research at the Helmholtz Zentrum München, German Center for Diabetes Research (DZD))

  • Valerie Gouon-Evans

    (Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai
    Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai
    Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai)

  • Andrew J. Sharp

    (Icahn School of Medicine at Mount Sinai)

  • Nicole C. Dubois

    (Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai
    Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai
    Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai)

Abstract

The recent identification of progenitor populations that contribute to the developing heart in a distinct spatial and temporal manner has fundamentally improved our understanding of cardiac development. However, the mechanisms that direct atrial versus ventricular specification remain largely unknown. Here we report the identification of a progenitor population that gives rise primarily to cardiovascular cells of the ventricles and only to few atrial cells (

Suggested Citation

  • Evan Bardot & Damelys Calderon & Francis Santoriello & Songyan Han & Kakit Cheung & Bharati Jadhav & Ingo Burtscher & Stanley Artap & Rajan Jain & Jonathan Epstein & Heiko Lickert & Valerie Gouon-Evan, 2017. "Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential," Nature Communications, Nature, vol. 8(1), pages 1-15, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14428
    DOI: 10.1038/ncomms14428
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