IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v8y2017i1d10.1038_ncomms14419.html
   My bibliography  Save this article

Foxn1-β5t transcriptional axis controls CD8+ T-cell production in the thymus

Author

Listed:
  • Muhammad Myn Uddin

    (Institute of Advanced Medical Sciences, University of Tokushima)

  • Izumi Ohigashi

    (Institute of Advanced Medical Sciences, University of Tokushima)

  • Ryo Motosugi

    (Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, University of Tokyo)

  • Tomomi Nakayama

    (Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, University of Tokyo)

  • Mie Sakata

    (Institute of Advanced Medical Sciences, University of Tokushima)

  • Jun Hamazaki

    (Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, University of Tokyo)

  • Yasumasa Nishito

    (Core Technology and Research Center, Tokyo Metropolitan Institute of Medical Science)

  • Immanuel Rode

    (German Cancer Research Center)

  • Keiji Tanaka

    (Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science)

  • Tatsuya Takemoto

    (Laboratory for Embryology, Institute of Advanced Medical Sciences, University of Tokushima)

  • Shigeo Murata

    (Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, University of Tokyo)

  • Yousuke Takahama

    (Institute of Advanced Medical Sciences, University of Tokushima)

Abstract

The thymus is an organ that produces functionally competent T cells that protect us from pathogens and malignancies. Foxn1 is a transcription factor that is essential for thymus organogenesis; however, the direct target for Foxn1 to actuate thymic T-cell production is unknown. Here we show that a Foxn1-binding cis-regulatory element promotes the transcription of β5t, which has an essential role in cortical thymic epithelial cells to induce positive selection of functionally competent CD8+ T cells. A point mutation in this genome element results in a defect in β5t expression and CD8+ T-cell production in mice. The results reveal a Foxn1-β5t transcriptional axis that governs CD8+ T-cell production in the thymus.

Suggested Citation

  • Muhammad Myn Uddin & Izumi Ohigashi & Ryo Motosugi & Tomomi Nakayama & Mie Sakata & Jun Hamazaki & Yasumasa Nishito & Immanuel Rode & Keiji Tanaka & Tatsuya Takemoto & Shigeo Murata & Yousuke Takahama, 2017. "Foxn1-β5t transcriptional axis controls CD8+ T-cell production in the thymus," Nature Communications, Nature, vol. 8(1), pages 1-10, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14419
    DOI: 10.1038/ncomms14419
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms14419
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms14419?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14419. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.