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A defined syphilis vaccine candidate inhibits dissemination of Treponema pallidum subspecies pallidum

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  • Karen V. Lithgow

    (University of Victoria)

  • Rebecca Hof

    (University of Victoria)

  • Charmaine Wetherell

    (University of Victoria)

  • Drew Phillips

    (University of Victoria)

  • Simon Houston

    (University of Victoria)

  • Caroline E. Cameron

    (University of Victoria)

Abstract

Syphilis is a prominent disease in low- and middle-income countries, and a re-emerging public health threat in high-income countries. Syphilis elimination will require development of an effective vaccine that has thus far remained elusive. Here we assess the vaccine potential of Tp0751, a vascular adhesin from the causative agent of syphilis, Treponema pallidum subsp. pallidum. Tp0751-immunized animals exhibit a significantly reduced bacterial organ burden upon T. pallidum challenge compared with unimmunized animals. Introduction of lymph nodes from Tp0751-immunized, T. pallidum-challenged animals to naive animals fails to induce infection, confirming sterile protection. These findings provide evidence that Tp0751 is a promising syphilis vaccine candidate.

Suggested Citation

  • Karen V. Lithgow & Rebecca Hof & Charmaine Wetherell & Drew Phillips & Simon Houston & Caroline E. Cameron, 2017. "A defined syphilis vaccine candidate inhibits dissemination of Treponema pallidum subspecies pallidum," Nature Communications, Nature, vol. 8(1), pages 1-10, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14273
    DOI: 10.1038/ncomms14273
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