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Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer

Author

Listed:
  • Thomas J. Hoffmann

    (University of California San Francisco
    Institute for Human Genetics, University of California San Francisco)

  • Michael N. Passarelli

    (University of California San Francisco)

  • Rebecca E. Graff

    (University of California San Francisco)

  • Nima C. Emami

    (University of California San Francisco)

  • Lori C. Sakoda

    (Kaiser Permanente, Northern California)

  • Eric Jorgenson

    (Kaiser Permanente, Northern California)

  • Laurel A. Habel

    (Kaiser Permanente, Northern California)

  • Jun Shan

    (Kaiser Permanente, Northern California)

  • Dilrini K. Ranatunga

    (Kaiser Permanente, Northern California)

  • Charles P. Quesenberry

    (Kaiser Permanente, Northern California)

  • Chun R. Chao

    (Kaiser Permanente Southern California)

  • Nirupa R. Ghai

    (Kaiser Permanente Southern California)

  • David Aaronson

    (Kaiser Oakland Medical Center, Northern California)

  • Joseph Presti

    (Kaiser Oakland Medical Center, Northern California)

  • Tobias Nordström

    (Karolinska Institutet)

  • Zhaoming Wang

    (Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health)

  • Sonja I. Berndt

    (Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health)

  • Stephen J. Chanock

    (Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health)

  • Jonathan D. Mosley

    (Vanderbilt University)

  • Robert J. Klein

    (Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
    Surgery, and Medicine, Memorial Sloan-Kettering Cancer Center
    University of Oxford
    Lund University)

  • Mridu Middha

    (Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
    Surgery, and Medicine, Memorial Sloan-Kettering Cancer Center
    University of Oxford
    Lund University)

  • Hans Lilja

    (Surgery, and Medicine, Memorial Sloan-Kettering Cancer Center
    University of Oxford
    Lund University)

  • Olle Melander

    (Lund University)

  • Mark N. Kvale

    (Institute for Human Genetics, University of California San Francisco)

  • Pui-Yan Kwok

    (Institute for Human Genetics, University of California San Francisco)

  • Catherine Schaefer

    (Kaiser Permanente, Northern California)

  • Neil Risch

    (University of California San Francisco
    Institute for Human Genetics, University of California San Francisco
    Kaiser Permanente, Northern California)

  • Stephen K. Van Den Eeden

    (Kaiser Permanente, Northern California
    University of California San Francisco)

  • John S. Witte

    (University of California San Francisco
    Institute for Human Genetics, University of California San Francisco
    University of California San Francisco)

Abstract

Prostate-specific antigen (PSA) levels have been used for detection and surveillance of prostate cancer (PCa). However, factors other than PCa—such as genetics—can impact PSA. Here we present findings from a genome-wide association study (GWAS) of PSA in 28,503 Kaiser Permanente whites and 17,428 men from replication cohorts. We detect 40 genome-wide significant (P

Suggested Citation

  • Thomas J. Hoffmann & Michael N. Passarelli & Rebecca E. Graff & Nima C. Emami & Lori C. Sakoda & Eric Jorgenson & Laurel A. Habel & Jun Shan & Dilrini K. Ranatunga & Charles P. Quesenberry & Chun R. C, 2017. "Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer," Nature Communications, Nature, vol. 8(1), pages 1-11, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14248
    DOI: 10.1038/ncomms14248
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