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JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling

Author

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  • Carles Recasens-Alvarez

    (Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology)

  • Ana Ferreira

    (Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology)

  • Marco Milán

    (Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
    Institució Catalana de Recerca i Estudis Avançats (ICREA))

Abstract

A stable pool of morphogen-producing cells is critical for the development of any organ or tissue. Here we present evidence that JAK/STAT signalling in the Drosophila wing promotes the cycling and survival of Hedgehog-producing cells, thereby allowing the stable localization of the nearby BMP/Dpp-organizing centre in the developing wing appendage. We identify the inhibitor of apoptosis dIAP1 and Cyclin A as two critical genes regulated by JAK/STAT and contributing to the growth of the Hedgehog-expressing cell population. We also unravel an early role of JAK/STAT in guaranteeing Wingless-mediated appendage specification, and a later one in restricting the Dpp-organizing activity to the appendage itself. These results unveil a fundamental role of the conserved JAK/STAT pathway in limb specification and growth by regulating morphogen production and signalling, and a function of pro-survival cues and mitogenic signals in the regulation of the pool of morphogen-producing cells in a developing organ.

Suggested Citation

  • Carles Recasens-Alvarez & Ana Ferreira & Marco Milán, 2017. "JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling," Nature Communications, Nature, vol. 8(1), pages 1-14, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms13815
    DOI: 10.1038/ncomms13815
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