IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v7y2016i1d10.1038_ncomms13437.html
   My bibliography  Save this article

Hierarchical zwitterionic modification of a SERS substrate enables real-time drug monitoring in blood plasma

Author

Listed:
  • Fang Sun

    (University of Washington)

  • Hsiang-Chieh Hung

    (University of Washington)

  • Andrew Sinclair

    (University of Washington)

  • Peng Zhang

    (University of Washington)

  • Tao Bai

    (University of Washington)

  • Daniel David Galvan

    (University of Washington)

  • Priyesh Jain

    (University of Washington)

  • Bowen Li

    (University of Washington)

  • Shaoyi Jiang

    (University of Washington
    University of Washington)

  • Qiuming Yu

    (University of Washington)

Abstract

Surface-enhanced Raman spectroscopy (SERS) is an ultrasensitive analytical technique with molecular specificity, making it an ideal candidate for therapeutic drug monitoring (TDM). However, in critical diagnostic media including blood, nonspecific protein adsorption coupled with weak surface affinities and small Raman activities of many analytes hinder the TDM application of SERS. Here we report a hierarchical surface modification strategy, first by coating a gold surface with a self-assembled monolayer (SAM) designed to attract or probe for analytes and then by grafting a non-fouling zwitterionic polymer brush layer to effectively repel protein fouling. We demonstrate how this modification can enable TDM applications by quantitatively and dynamically measuring the concentrations of several analytes—including an anticancer drug (doxorubicin), several TDM-requiring antidepressant and anti-seizure drugs, fructose and blood pH—in undiluted plasma. This hierarchical surface chemistry is widely applicable to many analytes and provides a generalized platform for SERS-based biosensing in complex real-world media.

Suggested Citation

  • Fang Sun & Hsiang-Chieh Hung & Andrew Sinclair & Peng Zhang & Tao Bai & Daniel David Galvan & Priyesh Jain & Bowen Li & Shaoyi Jiang & Qiuming Yu, 2016. "Hierarchical zwitterionic modification of a SERS substrate enables real-time drug monitoring in blood plasma," Nature Communications, Nature, vol. 7(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13437
    DOI: 10.1038/ncomms13437
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms13437
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms13437?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13437. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.