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Promotion of behavior and neuronal function by reactive oxygen species in C. elegans

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  • Guang Li

    (College of Life Science and Technology, Collective Innovation Center for Brain Science and Key Laboratory of Molecular Biophysics of MOE, Huazhong University of Science and Technology
    Life Sciences Institute, University of Michigan)

  • Jianke Gong

    (College of Life Science and Technology, Collective Innovation Center for Brain Science and Key Laboratory of Molecular Biophysics of MOE, Huazhong University of Science and Technology
    Life Sciences Institute, University of Michigan)

  • Haoyun Lei

    (College of Life Science and Technology, Collective Innovation Center for Brain Science and Key Laboratory of Molecular Biophysics of MOE, Huazhong University of Science and Technology
    Life Sciences Institute, University of Michigan)

  • Jianfeng Liu

    (College of Life Science and Technology, Collective Innovation Center for Brain Science and Key Laboratory of Molecular Biophysics of MOE, Huazhong University of Science and Technology)

  • X. Z. Shawn Xu

    (Life Sciences Institute, University of Michigan
    University of Michigan Medical School)

Abstract

Reactive oxygen species (ROS) are well known to elicit a plethora of detrimental effects on cellular functions by causing damages to proteins, lipids and nucleic acids. Neurons are particularly vulnerable to ROS, and nearly all forms of neurodegenerative diseases are associated with oxidative stress. Here, we report the surprising finding that exposing C. elegans to low doses of H2O2 promotes, rather than compromises, sensory behavior and the function of sensory neurons such as ASH. This beneficial effect of H2O2 is mediated by an evolutionarily conserved peroxiredoxin-p38/MAPK signaling cascade. We further show that p38/MAPK signals to AKT and the TRPV channel OSM-9, a sensory channel in ASH neurons. AKT phosphorylates OSM-9, and such phosphorylation is required for H2O2-induced potentiation of sensory behavior and ASH neuron function. Our results uncover a beneficial effect of ROS on neurons, revealing unexpected complexity of the action of oxidative stressors in the nervous system.

Suggested Citation

  • Guang Li & Jianke Gong & Haoyun Lei & Jianfeng Liu & X. Z. Shawn Xu, 2016. "Promotion of behavior and neuronal function by reactive oxygen species in C. elegans," Nature Communications, Nature, vol. 7(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13234
    DOI: 10.1038/ncomms13234
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    Cited by:

    1. John O. Onukwufor & M. Arsalan Farooqi & Anežka Vodičková & Shon A. Koren & Aksana Baldzizhar & Brandon J. Berry & Gisela Beutner & George A. Porter & Vsevolod Belousov & Alan Grossfield & Andrew P. W, 2022. "A reversible mitochondrial complex I thiol switch mediates hypoxic avoidance behavior in C. elegans," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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