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Electronic control of H+ current in a bioprotonic device with Gramicidin A and Alamethicin

Author

Listed:
  • Zahra Hemmatian

    (University of California Santa Cruz
    University of Washington)

  • Scott Keene

    (University of Washington)

  • Erik Josberger

    (University of Washington
    University of Washington)

  • Takeo Miyake

    (University of California Santa Cruz
    University of Washington)

  • Carina Arboleda

    (University of Washington)

  • Jessica Soto-Rodríguez

    (University of Washington)

  • François Baneyx

    (University of Washington)

  • Marco Rolandi

    (University of California Santa Cruz
    University of Washington)

Abstract

In biological systems, intercellular communication is mediated by membrane proteins and ion channels that regulate traffic of ions and small molecules across cell membranes. A bioelectronic device with ion channels that control ionic flow across a supported lipid bilayer (SLB) should therefore be ideal for interfacing with biological systems. Here, we demonstrate a biotic–abiotic bioprotonic device with Pd contacts that regulates proton (H+) flow across an SLB incorporating the ion channels Gramicidin A (gA) and Alamethicin (ALM). We model the device characteristics using the Goldman–Hodgkin–Katz (GHK) solution to the Nernst–Planck equation for transport across the membrane. We derive the permeability for an SLB integrating gA and ALM and demonstrate pH control as a function of applied voltage and membrane permeability. This work opens the door to integrating more complex H+ channels at the Pd contact interface to produce responsive biotic–abiotic devices with increased functionality.

Suggested Citation

  • Zahra Hemmatian & Scott Keene & Erik Josberger & Takeo Miyake & Carina Arboleda & Jessica Soto-Rodríguez & François Baneyx & Marco Rolandi, 2016. "Electronic control of H+ current in a bioprotonic device with Gramicidin A and Alamethicin," Nature Communications, Nature, vol. 7(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12981
    DOI: 10.1038/ncomms12981
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    Cited by:

    1. Le Luo & Swathi Manda & Yunjeong Park & Busra Demir & Jesse Sanchez & M. P. Anantram & Ersin Emre Oren & Ashwin Gopinath & Marco Rolandi, 2023. "DNA nanopores as artificial membrane channels for bioprotonics," Nature Communications, Nature, vol. 14(1), pages 1-10, December.

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