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MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis

Author

Listed:
  • Stefano Alivernini

    (Fondazione Policlinico Universitario A. Gemelli, Catholic University of the Sacred Heart)

  • Mariola Kurowska-Stolarska

    (Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary and Life Sciences, University of Glasgow)

  • Barbara Tolusso

    (Fondazione Policlinico Universitario A. Gemelli, Catholic University of the Sacred Heart)

  • Roberta Benvenuto

    (Fondazione Policlinico Universitario A. Gemelli, Catholic University of the Sacred Heart)

  • Aziza Elmesmari

    (Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary and Life Sciences, University of Glasgow)

  • Silvia Canestri

    (Fondazione Policlinico Universitario A. Gemelli, Catholic University of the Sacred Heart)

  • Luca Petricca

    (Fondazione Policlinico Universitario A. Gemelli, Catholic University of the Sacred Heart)

  • Antonella Mangoni

    (Fondazione Policlinico Universitario A. Gemelli, Catholic University of the Sacred Heart)

  • Anna Laura Fedele

    (Fondazione Policlinico Universitario A. Gemelli, Catholic University of the Sacred Heart)

  • Clara Di Mario

    (Fondazione Policlinico Universitario A. Gemelli, Catholic University of the Sacred Heart
    Fondazione Policlinico Universitario A. Gemelli, Catholic University of the Sacred Heart)

  • Maria Rita Gigante

    (Fondazione Policlinico Universitario A. Gemelli, Catholic University of the Sacred Heart)

  • Elisa Gremese

    (Fondazione Policlinico Universitario A. Gemelli, Catholic University of the Sacred Heart)

  • Iain B. McInnes

    (Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary and Life Sciences, University of Glasgow)

  • Gianfranco Ferraccioli

    (Fondazione Policlinico Universitario A. Gemelli, Catholic University of the Sacred Heart)

Abstract

MicroRNA-155 (miR-155) is an important regulator of B cells in mice. B cells have a critical role in the pathogenesis of rheumatoid arthritis (RA). Here we show that miR-155 is highly expressed in peripheral blood B cells from RA patients compared with healthy individuals, particularly in the IgD-CD27- memory B-cell population in ACPA+ RA. MiR-155 is highly expressed in RA B cells from patients with synovial tissue containing ectopic germinal centres compared with diffuse synovial tissue. MiR-155 expression is associated reciprocally with lower expression of PU.1 at B-cell level in the synovial compartment. Stimulation of healthy donor B cells with CD40L, anti-IgM, IL-21, CpG, IFN-α, IL-6 or BAFF induces miR-155 and decreases PU.1 expression. Finally, inhibition of endogenous miR-155 in B cells of RA patients restores PU.1 and reduces production of antibodies. Our data suggest that miR-155 is an important regulator of B-cell activation in RA.

Suggested Citation

  • Stefano Alivernini & Mariola Kurowska-Stolarska & Barbara Tolusso & Roberta Benvenuto & Aziza Elmesmari & Silvia Canestri & Luca Petricca & Antonella Mangoni & Anna Laura Fedele & Clara Di Mario & Mar, 2016. "MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis," Nature Communications, Nature, vol. 7(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12970
    DOI: 10.1038/ncomms12970
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