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FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon

Author

Listed:
  • Katarzyna Dover

    (Hunter College of City University
    Graduate Center of City University, Molecular, Cellular and Developmental Biology Subprogram)

  • Christopher Marra

    (Hunter College of City University
    Graduate Center of City University, Neuroscience Subprogram)

  • Sergio Solinas

    (Brain Connectivity Center, C. Mondino National Neurological Institute
    Present address: Department of Biomedical Science, University of Sassari, Viale San Pietro 43/c, Sassari 07100, Italy)

  • Marko Popovic

    (Yale University School of Medicine
    Present address: Netherlands Institute for Neuroscience, Meiberdreef 47, 1105 BA Amsterdam, The Netherlands)

  • Sathyaa Subramaniyam

    (University of Pavia)

  • Dejan Zecevic

    (Yale University School of Medicine)

  • Egidio D’Angelo

    (Brain Connectivity Center, C. Mondino National Neurological Institute
    University of Pavia)

  • Mitchell Goldfarb

    (Hunter College of City University
    Graduate Center of City University, Neuroscience Subprogram)

Abstract

Neurons in vertebrate central nervous systems initiate and conduct sodium action potentials in distinct subcellular compartments that differ architecturally and electrically. Here, we report several unanticipated passive and active properties of the cerebellar granule cell’s unmyelinated axon. Whereas spike initiation at the axon initial segment relies on sodium channel (Nav)-associated fibroblast growth factor homologous factor (FHF) proteins to delay Nav inactivation, distal axonal Navs show little FHF association or FHF requirement for high-frequency transmission, velocity and waveforms of conducting action potentials. In addition, leak conductance density along the distal axon is estimated as

Suggested Citation

  • Katarzyna Dover & Christopher Marra & Sergio Solinas & Marko Popovic & Sathyaa Subramaniyam & Dejan Zecevic & Egidio D’Angelo & Mitchell Goldfarb, 2016. "FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon," Nature Communications, Nature, vol. 7(1), pages 1-11, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12895
    DOI: 10.1038/ncomms12895
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