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Stereotyped initiation of retinal waves by bipolar cells via presynaptic NMDA autoreceptors

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  • Rong-wei Zhang

    (Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences)

  • Xiao-quan Li

    (Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences)

  • Koichi Kawakami

    (National Institute of Genetics)

  • Jiu-lin Du

    (Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
    School of Life Science and Technology, ShanghaiTech University
    University of Chinese Academy of Sciences)

Abstract

Glutamatergic retinal waves, the spontaneous patterned neural activities propagating among developing retinal ganglion cells (RGCs), instruct the activity-dependent refinement of visuotopic maps. However, its initiation and underlying mechanism remain largely elusive. Here using larval zebrafish and multiple in vivo approaches, we discover that bipolar cells (BCs) are responsible for the generation of glutamatergic retinal waves. The wave originates from BC axon terminals (ATs) and propagates laterally to nearby BCs and vertically to downstream RGCs and the optic tectum. Its initiation is triggered by the activation of and consequent glutamate release from BC ATs, and is mediated by the N-methyl-D-aspartate subtype of glutamate receptors (NMDARs) expressed at these ATs. Intercellular asymmetry of NMDAR expression at BC ATs enables the preferential initiation of waves at the temporal retina, where BC ATs express more NMDARs. Thus, our findings indicate that glutamatergic retinal waves are initiated by BCs through a presynaptic NMDA autoreceptor-dependent process.

Suggested Citation

  • Rong-wei Zhang & Xiao-quan Li & Koichi Kawakami & Jiu-lin Du, 2016. "Stereotyped initiation of retinal waves by bipolar cells via presynaptic NMDA autoreceptors," Nature Communications, Nature, vol. 7(1), pages 1-12, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12650
    DOI: 10.1038/ncomms12650
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    Cited by:

    1. Yang Zhao & Chun-Xiao Huang & Yiming Gu & Yacong Zhao & Wenjie Ren & Yutong Wang & Jinjin Chen & Na N. Guan & Jianren Song, 2024. "Serotonergic modulation of vigilance states in zebrafish and mice," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Shachar Sherman & Irene Arnold-Ammer & Martin W. Schneider & Koichi Kawakami & Herwig Baier, 2023. "Retina-derived signals control pace of neurogenesis in visual brain areas but not circuit assembly," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Dániel L. Barabási & Gregor F. P. Schuhknecht & Florian Engert, 2024. "Functional neuronal circuits emerge in the absence of developmental activity," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    4. Fangying Zhao & Jiangyong He & Jun Tang & Nianfei Cui & Yanyan Shi & Zhifan Li & Shengnan Liu & Yazhou Wang & Ming Ma & Congjian Zhao & Lingfei Luo & Li Li, 2022. "Brain milieu induces early microglial maturation through the BAX-Notch axis," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    5. Chun-Xiao Huang & Yacong Zhao & Jie Mao & Zhen Wang & Lulu Xu & Jianwei Cheng & Na N. Guan & Jianren Song, 2021. "An injury-induced serotonergic neuron subpopulation contributes to axon regrowth and function restoration after spinal cord injury in zebrafish," Nature Communications, Nature, vol. 12(1), pages 1-13, December.

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