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Optogenetically enhanced pituitary corticotroph cell activity post-stress onset causes rapid organizing effects on behaviour

Author

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  • Rodrigo J. De Marco

    (Developmental Genetics of the Nervous System, Max Planck Institute for Medical Research)

  • Theresa Thiemann

    (Developmental Genetics of the Nervous System, Max Planck Institute for Medical Research)

  • Antonia H. Groneberg

    (Developmental Genetics of the Nervous System, Max Planck Institute for Medical Research
    Present address: Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, 2 andar Avenue Brasília, Doca de Pedrouços, 1400-038 Lisbon, Portugal)

  • Ulrich Herget

    (Developmental Genetics of the Nervous System, Max Planck Institute for Medical Research
    Present addresses: Division of Biology and Biological Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA)

  • Soojin Ryu

    (Developmental Genetics of the Nervous System, Max Planck Institute for Medical Research
    Focus Program Translational Neuroscience, Johannes Gutenberg University Medical Center)

Abstract

The anterior pituitary is the major link between nervous and hormonal systems, which allow the brain to generate adequate and flexible behaviour. Here, we address its role in mediating behavioural adjustments that aid in coping with acutely threatening environments. For this we combine optogenetic manipulation of pituitary corticotroph cells in larval zebrafish with newly developed assays for measuring goal-directed actions in very short timescales. Our results reveal modulatory actions of corticotroph cell activity on locomotion, avoidance behaviours and stimulus responsiveness directly after the onset of stress. Altogether, the findings uncover the significance of endocrine pituitary cells for rapidly optimizing behaviour in local antagonistic environments.

Suggested Citation

  • Rodrigo J. De Marco & Theresa Thiemann & Antonia H. Groneberg & Ulrich Herget & Soojin Ryu, 2016. "Optogenetically enhanced pituitary corticotroph cell activity post-stress onset causes rapid organizing effects on behaviour," Nature Communications, Nature, vol. 7(1), pages 1-11, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12620
    DOI: 10.1038/ncomms12620
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