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Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma

Author

Listed:
  • Harvind S. Chahal

    (Stanford University School of Medicine)

  • Wenting Wu

    (Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University)

  • Katherine J. Ransohoff

    (Stanford University School of Medicine)

  • Lingyao Yang

    (Stanford University School of Medicine)

  • Haley Hedlin

    (Stanford University School of Medicine)

  • Manisha Desai

    (Stanford University School of Medicine)

  • Yuan Lin

    (Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University)

  • Hong-Ji Dai

    (Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University
    Tianjin Medical University Cancer Hospital and Institute, National Clinical Research Center for Cancer, Tianjin & Key Laboratory of Cancer Prevention and Therapy)

  • Abrar A. Qureshi

    (Warren Alpert Medical School, Brown University
    School of Public Health, Brown University
    Brigham and Women's Hospital, Harvard Medical School)

  • Wen-Qing Li

    (Warren Alpert Medical School, Brown University
    School of Public Health, Brown University)

  • Peter Kraft

    (Harvard T.H. Chan School of Public Health
    Harvard T.H. Chan School of Public Health)

  • David A. Hinds

    (23andMe Inc.)

  • Jean Y. Tang

    (Stanford University School of Medicine)

  • Jiali Han

    (Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University
    Tianjin Medical University Cancer Hospital and Institute, National Clinical Research Center for Cancer, Tianjin & Key Laboratory of Cancer Prevention and Therapy
    Harvard T.H. Chan School of Public Health)

  • Kavita Y. Sarin

    (Stanford University School of Medicine)

Abstract

Basal cell carcinoma (BCC) is the most common cancer worldwide with an annual incidence of 2.8 million cases in the United States alone. Previous studies have demonstrated an association between 21 distinct genetic loci and BCC risk. Here, we report the results of a two-stage genome-wide association study of BCC, totalling 17,187 cases and 287,054 controls. We confirm 17 previously reported loci and identify 14 new susceptibility loci reaching genome-wide significance (P

Suggested Citation

  • Harvind S. Chahal & Wenting Wu & Katherine J. Ransohoff & Lingyao Yang & Haley Hedlin & Manisha Desai & Yuan Lin & Hong-Ji Dai & Abrar A. Qureshi & Wen-Qing Li & Peter Kraft & David A. Hinds & Jean Y., 2016. "Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma," Nature Communications, Nature, vol. 7(1), pages 1-10, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12510
    DOI: 10.1038/ncomms12510
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    Cited by:

    1. Pietro Biroli & Titus J. Galama & Stephanie von Hinke & Hans van Kippersluis & Cornelius A. Rietveld & Kevin Thom, 2022. "The Economics and Econometrics of Gene-Environment Interplay," Papers 2203.00729, arXiv.org.
    2. Mathias Seviiri & Matthew H. Law & Jue-Sheng Ong & Puya Gharahkhani & Pierre Fontanillas & Catherine M. Olsen & David C. Whiteman & Stuart MacGregor, 2022. "A multi-phenotype analysis reveals 19 susceptibility loci for basal cell carcinoma and 15 for squamous cell carcinoma," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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