IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v7y2016i1d10.1038_ncomms12343.html
   My bibliography  Save this article

Deconvoluting hepatic processing of carbon nanotubes

Author

Listed:
  • Simone Alidori

    (Memorial Sloan-Kettering Cancer Center)

  • Robert L. Bowman

    (Memorial Sloan-Kettering Cancer Center)

  • Dmitry Yarilin

    (Molecular Cytology Core Facility, Memorial Sloan-Kettering Cancer Center)

  • Yevgeniy Romin

    (Molecular Cytology Core Facility, Memorial Sloan-Kettering Cancer Center)

  • Afsar Barlas

    (Molecular Cytology Core Facility, Memorial Sloan-Kettering Cancer Center)

  • J. Justin Mulvey

    (Memorial Sloan-Kettering Cancer Center)

  • Sho Fujisawa

    (Molecular Cytology Core Facility, Memorial Sloan-Kettering Cancer Center)

  • Ke Xu

    (Molecular Cytology Core Facility, Memorial Sloan-Kettering Cancer Center)

  • Alessandro Ruggiero

    (Papworth Hospital NHS Foundation Trust, Cambridge University Health Partners)

  • Vladimir Riabov

    (Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Ruprecht-Karls University of Heidelberg
    Laboratory for Translational Cellular and Molecular Biomedicine, Tomsk State University)

  • Daniel L. J. Thorek

    (Johns Hopkins School of Medicine)

  • Hans David S. Ulmert

    (Memorial Sloan-Kettering Cancer Center)

  • Elliott J. Brea

    (Memorial Sloan-Kettering Cancer Center)

  • Katja Behling

    (Memorial Sloan-Kettering Cancer Center)

  • Julia Kzhyshkowska

    (Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Ruprecht-Karls University of Heidelberg
    Laboratory for Translational Cellular and Molecular Biomedicine, Tomsk State University
    Red Cross Blood Service Baden-Württemberg-Hessen)

  • Katia Manova-Todorova

    (Molecular Cytology Core Facility, Memorial Sloan-Kettering Cancer Center)

  • David A. Scheinberg

    (Memorial Sloan-Kettering Cancer Center
    Weill Cornell Medical College)

  • Michael R. McDevitt

    (Memorial Sloan-Kettering Cancer Center
    Weill Cornell Medical College)

Abstract

Single-wall carbon nanotubes present unique opportunities for drug delivery, but have not advanced into the clinic. Differential nanotube accretion and clearance from critical organs have been observed, but the mechanism not fully elucidated. The liver has a complex cellular composition that regulates a range of metabolic functions and coincidently accumulates most particulate drugs. Here we provide the unexpected details of hepatic processing of covalently functionalized nanotubes including receptor-mediated endocytosis, cellular trafficking and biliary elimination. Ammonium-functionalized fibrillar nanocarbon is found to preferentially localize in the fenestrated sinusoidal endothelium of the liver but not resident macrophages. Stabilin receptors mediate the endocytic clearance of nanotubes. Biocompatibility is evidenced by the absence of cell death and no immune cell infiltration. Towards clinical application of this platform, nanotubes were evaluated for the first time in non-human primates. The pharmacologic profile in cynomolgus monkeys is equivalent to what was reported in mice and suggests that nanotubes should behave similarly in humans.

Suggested Citation

  • Simone Alidori & Robert L. Bowman & Dmitry Yarilin & Yevgeniy Romin & Afsar Barlas & J. Justin Mulvey & Sho Fujisawa & Ke Xu & Alessandro Ruggiero & Vladimir Riabov & Daniel L. J. Thorek & Hans David , 2016. "Deconvoluting hepatic processing of carbon nanotubes," Nature Communications, Nature, vol. 7(1), pages 1-11, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12343
    DOI: 10.1038/ncomms12343
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms12343
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms12343?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12343. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.