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Protein kinase A modulation of CaV1.4 calcium channels

Author

Listed:
  • Lingjie Sang

    (Calcium Signals Laboratory, The Johns Hopkins University School of Medicine)

  • Ivy E. Dick

    (Calcium Signals Laboratory, The Johns Hopkins University School of Medicine)

  • David T. Yue

    (Calcium Signals Laboratory, The Johns Hopkins University School of Medicine
    The Johns Hopkins University School of Medicine)

Abstract

The regulation of L-type Ca2+ channels by protein kinase A (PKA) represents a crucial element within cardiac, skeletal muscle and neurological systems. Although much work has been done to understand this regulation in cardiac CaV1.2 Ca2+ channels, relatively little is known about the closely related CaV1.4 L-type Ca2+ channels, which feature prominently in the visual system. Here we find that CaV1.4 channels are indeed modulated by PKA phosphorylation within the inhibitor of Ca2+-dependent inactivation (ICDI) motif. Phosphorylation of this region promotes the occupancy of calmodulin on the channel, thus increasing channel open probability (PO) and Ca2+-dependent inactivation. Although this interaction seems specific to CaV1.4 channels, introduction of ICDI1.4 to CaV1.3 or CaV1.2 channels endows these channels with a form of PKA modulation, previously unobserved in heterologous systems. Thus, this mechanism may not only play an important role in the visual system but may be generalizable across the L-type channel family.

Suggested Citation

  • Lingjie Sang & Ivy E. Dick & David T. Yue, 2016. "Protein kinase A modulation of CaV1.4 calcium channels," Nature Communications, Nature, vol. 7(1), pages 1-11, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12239
    DOI: 10.1038/ncomms12239
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