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Envelope-specific B-cell populations in African green monkeys chronically infected with simian immunodeficiency virus

Author

Listed:
  • Ruijun Zhang

    (Duke Human Vaccine Institute, Duke University School of Medicine)

  • David R. Martinez

    (Duke Human Vaccine Institute, Duke University School of Medicine)

  • Quang N. Nguyen

    (Duke Human Vaccine Institute, Duke University School of Medicine)

  • Justin Pollara

    (Duke Human Vaccine Institute, Duke University School of Medicine
    Duke University Medical Center)

  • Trina Arifin

    (Duke Human Vaccine Institute, Duke University School of Medicine)

  • Christina Stolarchuk

    (Duke Human Vaccine Institute, Duke University School of Medicine)

  • Andrew Foulger

    (Duke Human Vaccine Institute, Duke University School of Medicine)

  • Josh D. Amos

    (Duke Human Vaccine Institute, Duke University School of Medicine)

  • Robert Parks

    (Duke Human Vaccine Institute, Duke University School of Medicine)

  • Jonathon E. Himes

    (Duke Human Vaccine Institute, Duke University School of Medicine)

  • Minyue Wang

    (Duke Human Vaccine Institute, Duke University School of Medicine)

  • Regina W. Edwards

    (Duke Human Vaccine Institute, Duke University School of Medicine)

  • Ashley M. Trama

    (Duke Human Vaccine Institute, Duke University School of Medicine)

  • Nathan Vandergrift

    (Duke Human Vaccine Institute, Duke University School of Medicine)

  • Lisa Colvin

    (Duke Human Vaccine Institute, Duke University School of Medicine)

  • Ken Dewar

    (Research Institute of the McGill University Health Centre, McGill University and Génome Québec Innovation Centre
    McGill University
    McGill University)

  • Nikoleta Juretic

    (Research Institute of the McGill University Health Centre, McGill University and Génome Québec Innovation Centre
    McGill University
    McGill University)

  • Jessica Wasserscheid

    (Research Institute of the McGill University Health Centre, McGill University and Génome Québec Innovation Centre
    McGill University
    McGill University)

  • Guido Ferrari

    (Duke Human Vaccine Institute, Duke University School of Medicine
    Duke University Medical Center)

  • Hua-Xin Liao

    (Duke Human Vaccine Institute, Duke University School of Medicine)

  • Sallie R. Permar

    (Duke Human Vaccine Institute, Duke University School of Medicine
    Duke University Medical Center)

Abstract

African green monkeys (AGMs) are natural primate hosts of simian immunodeficiency virus (SIV). Interestingly, features of the envelope-specific antibody responses in SIV-infected AGMs are distinct from that of HIV-infected humans and SIV-infected rhesus monkeys, including gp120-focused responses and rapid development of autologous neutralization. Yet, the lack of genetic tools to evaluate B-cell lineages hinders potential use of this unique non-human primate model for HIV vaccine development. Here we define features of the AGM Ig loci and compare the proportion of Env-specific memory B-cell populations to that of HIV-infected humans and SIV-infected rhesus monkeys. AGMs appear to have a higher proportion of Env-specific memory B cells that are mainly gp120 directed. Furthermore, AGM gp120-specific monoclonal antibodies display robust antibody-dependent cellular cytotoxicity and CD4-dependent virion capture activity. Our results support the use of AGMs to model induction of functional gp120-specific antibodies by HIV vaccine strategies.

Suggested Citation

  • Ruijun Zhang & David R. Martinez & Quang N. Nguyen & Justin Pollara & Trina Arifin & Christina Stolarchuk & Andrew Foulger & Josh D. Amos & Robert Parks & Jonathon E. Himes & Minyue Wang & Regina W. E, 2016. "Envelope-specific B-cell populations in African green monkeys chronically infected with simian immunodeficiency virus," Nature Communications, Nature, vol. 7(1), pages 1-11, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12131
    DOI: 10.1038/ncomms12131
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