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Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states

Author

Listed:
  • Antony Adamson

    (Systems Microscopy Centre, Faculty of Life Sciences, University of Manchester)

  • Christopher Boddington

    (Systems Microscopy Centre, Faculty of Life Sciences, University of Manchester)

  • Polly Downton

    (Systems Microscopy Centre, Faculty of Life Sciences, University of Manchester)

  • William Rowe

    (Systems Microscopy Centre, Faculty of Life Sciences, University of Manchester)

  • James Bagnall

    (Systems Microscopy Centre, Faculty of Life Sciences, University of Manchester)

  • Connie Lam

    (Systems Microscopy Centre, Faculty of Life Sciences, University of Manchester)

  • Apolinar Maya-Mendoza

    (The Danish Cancer Society Research Center)

  • Lorraine Schmidt

    (Systems Microscopy Centre, Faculty of Life Sciences, University of Manchester)

  • Claire V. Harper

    (Systems Microscopy Centre, Faculty of Life Sciences, University of Manchester)

  • David G. Spiller

    (Systems Microscopy Centre, Faculty of Life Sciences, University of Manchester)

  • David A. Rand

    (Warwick Systems Biology and Mathematics Institute, University of Warwick)

  • Dean A. Jackson

    (Systems Microscopy Centre, Faculty of Life Sciences, University of Manchester)

  • Michael R. H. White

    (Systems Microscopy Centre, Faculty of Life Sciences, University of Manchester)

  • Pawel Paszek

    (Systems Microscopy Centre, Faculty of Life Sciences, University of Manchester)

Abstract

Cells respond dynamically to pulsatile cytokine stimulation. Here we report that single, or well-spaced pulses of TNFα (>100 min apart) give a high probability of NF-κB activation. However, fewer cells respond to shorter pulse intervals (

Suggested Citation

  • Antony Adamson & Christopher Boddington & Polly Downton & William Rowe & James Bagnall & Connie Lam & Apolinar Maya-Mendoza & Lorraine Schmidt & Claire V. Harper & David G. Spiller & David A. Rand & D, 2016. "Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states," Nature Communications, Nature, vol. 7(1), pages 1-14, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12057
    DOI: 10.1038/ncomms12057
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