IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v7y2016i1d10.1038_ncomms12048.html
   My bibliography  Save this article

Genome-wide association study identifies novel susceptibility loci for cutaneous squamous cell carcinoma

Author

Listed:
  • Harvind S. Chahal

    (Stanford University School of Medicine)

  • Yuan Lin

    (Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University)

  • Katherine J. Ransohoff

    (Stanford University School of Medicine)

  • David A. Hinds

    (23andMe Inc.)

  • Wenting Wu

    (Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University)

  • Hong-Ji Dai

    (Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University
    Tianjin Medical University Cancer Hospital and Institute, National Clinical Research Center for Cancer, Tianjin & Key Laboratory of Cancer Prevention and Therapy)

  • Abrar A. Qureshi

    (Warren Alpert Medical School, Brown University
    School of Public Health, Brown University
    Brigham and Women’s Hospital, Harvard Medical School)

  • Wen-Qing Li

    (Warren Alpert Medical School, Brown University
    School of Public Health, Brown University)

  • Peter Kraft

    (Harvard T.H. Chan School of Public Health
    Harvard T.H. Chan School of Public Health)

  • Jean Y. Tang

    (Stanford University School of Medicine)

  • Jiali Han

    (Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University
    Tianjin Medical University Cancer Hospital and Institute, National Clinical Research Center for Cancer, Tianjin & Key Laboratory of Cancer Prevention and Therapy
    Harvard T.H. Chan School of Public Health)

  • Kavita Y. Sarin

    (Stanford University School of Medicine)

Abstract

Cutaneous squamous cell carcinoma represents the second most common cutaneous malignancy, affecting 7–11% of Caucasians in the United States. The genetic determinants of susceptibility to cutaneous squamous cell carcinoma remain largely unknown. Here we report the results of a two-stage genome-wide association study of cutaneous squamous cell carcinoma, totalling 7,404 cases and 292,076 controls. Eleven loci reached genome-wide significance (P

Suggested Citation

  • Harvind S. Chahal & Yuan Lin & Katherine J. Ransohoff & David A. Hinds & Wenting Wu & Hong-Ji Dai & Abrar A. Qureshi & Wen-Qing Li & Peter Kraft & Jean Y. Tang & Jiali Han & Kavita Y. Sarin, 2016. "Genome-wide association study identifies novel susceptibility loci for cutaneous squamous cell carcinoma," Nature Communications, Nature, vol. 7(1), pages 1-8, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12048
    DOI: 10.1038/ncomms12048
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms12048
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms12048?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Meghana Pagadala & Timothy J. Sears & Victoria H. Wu & Eva Pérez-Guijarro & Hyo Kim & Andrea Castro & James V. Talwar & Cristian Gonzalez-Colin & Steven Cao & Benjamin J. Schmiedel & Shervin Goudarzi , 2023. "Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    2. Mathias Seviiri & Matthew H. Law & Jue-Sheng Ong & Puya Gharahkhani & Pierre Fontanillas & Catherine M. Olsen & David C. Whiteman & Stuart MacGregor, 2022. "A multi-phenotype analysis reveals 19 susceptibility loci for basal cell carcinoma and 15 for squamous cell carcinoma," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Gianmarco Mignogna & Caitlin E. Carey & Robbee Wedow & Nikolas Baya & Mattia Cordioli & Nicola Pirastu & Rino Bellocco & Kathryn Fiuza Malerbi & Michel G. Nivard & Benjamin M. Neale & Raymond K. Walte, 2023. "Patterns of item nonresponse behaviour to survey questionnaires are systematic and associated with genetic loci," Nature Human Behaviour, Nature, vol. 7(8), pages 1371-1387, August.
    4. James J. Gilchrist & Seiko Makino & Vivek Naranbhai & Piyush K. Sharma & Surya Koturan & Orion Tong & Chelsea A. Taylor & Robert A. Watson & Alba Verge los Aires & Rosalin Cooper & Evelyn Lau & Sara D, 2022. "Natural Killer cells demonstrate distinct eQTL and transcriptome-wide disease associations, highlighting their role in autoimmunity," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    5. Ke Mao & Christelle Borel & Muhammad Ansar & Angad Jolly & Periklis Makrythanasis & Christine Froehlich & Justyna Iwaszkiewicz & Bingqing Wang & Xiaopeng Xu & Qiang Li & Xavier Blanc & Hao Zhu & Qi Ch, 2023. "FOXI3 pathogenic variants cause one form of craniofacial microsomia," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12048. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.