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Circadian regulation of human cortical excitability

Author

Listed:
  • Julien Q. M. Ly

    (GIGA-Research, Cyclotron Research Centre–In Vivo Imaging Unit, University of Liège
    Walloon excellence in life sciences and biotechnology (WELBIO)
    Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart Tilman)

  • Giulia Gaggioni

    (GIGA-Research, Cyclotron Research Centre–In Vivo Imaging Unit, University of Liège
    Walloon excellence in life sciences and biotechnology (WELBIO))

  • Sarah L. Chellappa

    (GIGA-Research, Cyclotron Research Centre–In Vivo Imaging Unit, University of Liège
    Walloon excellence in life sciences and biotechnology (WELBIO))

  • Soterios Papachilleos

    (GIGA-Research, Cyclotron Research Centre–In Vivo Imaging Unit, University of Liège
    Walloon excellence in life sciences and biotechnology (WELBIO))

  • Alexandre Brzozowski

    (GIGA-Research, Cyclotron Research Centre–In Vivo Imaging Unit, University of Liège
    Walloon excellence in life sciences and biotechnology (WELBIO))

  • Chloé Borsu

    (GIGA-Research, Cyclotron Research Centre–In Vivo Imaging Unit, University of Liège
    Walloon excellence in life sciences and biotechnology (WELBIO))

  • Mario Rosanova

    (Universit degli Studi di Milano
    Fondazione Europea Di Ricerca Biomedica)

  • Simone Sarasso

    (Universit degli Studi di Milano)

  • Benita Middleton

    (Surrey Sleep Research Centre, University of Surrey)

  • André Luxen

    (GIGA-Research, Cyclotron Research Centre–In Vivo Imaging Unit, University of Liège
    Walloon excellence in life sciences and biotechnology (WELBIO))

  • Simon N. Archer

    (Surrey Sleep Research Centre, University of Surrey)

  • Christophe Phillips

    (GIGA-Research, Cyclotron Research Centre–In Vivo Imaging Unit, University of Liège
    Walloon excellence in life sciences and biotechnology (WELBIO))

  • Derk-Jan Dijk

    (Surrey Sleep Research Centre, University of Surrey)

  • Pierre Maquet

    (GIGA-Research, Cyclotron Research Centre–In Vivo Imaging Unit, University of Liège
    Walloon excellence in life sciences and biotechnology (WELBIO)
    Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart Tilman)

  • Marcello Massimini

    (Universit degli Studi di Milano)

  • Gilles Vandewalle

    (GIGA-Research, Cyclotron Research Centre–In Vivo Imaging Unit, University of Liège
    Walloon excellence in life sciences and biotechnology (WELBIO))

Abstract

Prolonged wakefulness alters cortical excitability, which is essential for proper brain function and cognition. However, besides prior wakefulness, brain function and cognition are also affected by circadian rhythmicity. Whether the regulation of cognition involves a circadian impact on cortical excitability is unknown. Here, we assessed cortical excitability from scalp electroencephalography (EEG) responses to transcranial magnetic stimulation in 22 participants during 29 h of wakefulness under constant conditions. Data reveal robust circadian dynamics of cortical excitability that are strongest in those individuals with highest endocrine markers of circadian amplitude. In addition, the time course of cortical excitability correlates with changes in EEG synchronization and cognitive performance. These results demonstrate that the crucial factor for cortical excitability, and basic brain function in general, is the balance between circadian rhythmicity and sleep need, rather than sleep homoeostasis alone. These findings have implications for clinical applications such as non-invasive brain stimulation in neurorehabilitation.

Suggested Citation

  • Julien Q. M. Ly & Giulia Gaggioni & Sarah L. Chellappa & Soterios Papachilleos & Alexandre Brzozowski & Chloé Borsu & Mario Rosanova & Simone Sarasso & Benita Middleton & André Luxen & Simon N. Archer, 2016. "Circadian regulation of human cortical excitability," Nature Communications, Nature, vol. 7(1), pages 1-10, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11828
    DOI: 10.1038/ncomms11828
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