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Activity-dependent plasticity of hippocampal place maps

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  • Philipp Schoenenberger

    (Institute of Science and Technology Austria, Am Campus 1, A–3400 Klosterneuburg, Austria
    Present address: F. Hoffmann-La Roche Ltd, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland.)

  • Joseph O’Neill

    (Institute of Science and Technology Austria, Am Campus 1, A–3400 Klosterneuburg, Austria)

  • Jozsef Csicsvari

    (Institute of Science and Technology Austria, Am Campus 1, A–3400 Klosterneuburg, Austria)

Abstract

Hippocampal neurons encode a cognitive map of space. These maps are thought to be updated during learning and in response to changes in the environment through activity-dependent synaptic plasticity. Here we examine how changes in activity influence spatial coding in rats using halorhodopsin-mediated, spatially selective optogenetic silencing. Halorhoposin stimulation leads to light-induced suppression in many place cells and interneurons; some place cells increase their firing through disinhibition, whereas some show no effect. We find that place fields of the unaffected subpopulation remain stable. On the other hand, place fields of suppressed place cells were unstable, showing remapping across sessions before and after optogenetic inhibition. Disinhibited place cells had stable maps but sustained an elevated firing rate. These findings suggest that place representation in the hippocampus is constantly governed by activity-dependent processes, and that disinhibition may provide a mechanism for rate remapping.

Suggested Citation

  • Philipp Schoenenberger & Joseph O’Neill & Jozsef Csicsvari, 2016. "Activity-dependent plasticity of hippocampal place maps," Nature Communications, Nature, vol. 7(1), pages 1-12, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11824
    DOI: 10.1038/ncomms11824
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