IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v7y2016i1d10.1038_ncomms11716.html
   My bibliography  Save this article

Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM

Author

Listed:
  • Hongming Miao

    (Southwest Hospital, The Third Military Medical University)

  • Juanjuan Ou

    (Southwest Hospital, The Third Military Medical University)

  • Yuan Peng

    (Southwest Hospital, The Third Military Medical University)

  • Xuan Zhang

    (Southwest Hospital, The Third Military Medical University)

  • Yujuan Chen

    (Southwest Hospital, The Third Military Medical University)

  • Lijun Hao

    (Southwest Hospital, The Third Military Medical University)

  • Ganfeng Xie

    (Southwest Hospital, The Third Military Medical University)

  • Zhe Wang

    (Southwest Hospital, The Third Military Medical University)

  • Xueli Pang

    (Southwest Hospital, The Third Military Medical University)

  • Zhihua Ruan

    (Southwest Hospital, The Third Military Medical University)

  • Jianjun Li

    (Southwest Hospital, The Third Military Medical University)

  • Liqing Yu

    (University of Maryland)

  • Bingzhong Xue

    (Georgia State University)

  • Hang Shi

    (Georgia State University)

  • Chunmeng Shi

    (Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University)

  • Houjie Liang

    (Southwest Hospital, The Third Military Medical University)

Abstract

Metabolic reprogramming in stromal cells plays an essential role in regulating tumour growth. The metabolic activities of tumour-associated macrophages (TAMs) in colorectal cancer (CRC) are incompletely characterized. Here, we identify TAM-derived factors and their roles in the development of CRC. We demonstrate that ABHD5, a lipolytic co-activator, is ectopically expressed in CRC-associated macrophages. We demonstrate in vitro and in mouse models that macrophage ABHD5 potentiates growth of CRC cells. Mechanistically, ABHD5 suppresses spermidine synthase (SRM)-dependent spermidine production in macrophages by inhibiting the reactive oxygen species-dependent expression of C/EBPɛ, which activates transcription of the srm gene. Notably, macrophage-specific ABHD5 transgene-induced CRC growth in mice can be prevented by an additional SRM transgene in macrophages. Altogether, our results show that the lipolytic factor ABHD5 suppresses SRM-dependent spermidine production in TAMs and potentiates the growth of CRC. The ABHD5/SRM/spermidine axis in TAMs might represent a potential target for therapy.

Suggested Citation

  • Hongming Miao & Juanjuan Ou & Yuan Peng & Xuan Zhang & Yujuan Chen & Lijun Hao & Ganfeng Xie & Zhe Wang & Xueli Pang & Zhihua Ruan & Jianjun Li & Liqing Yu & Bingzhong Xue & Hang Shi & Chunmeng Shi & , 2016. "Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM," Nature Communications, Nature, vol. 7(1), pages 1-12, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11716
    DOI: 10.1038/ncomms11716
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms11716
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms11716?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11716. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.