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Genome-wide association study identifies 8p21.3 associated with persistent hepatitis B virus infection among Chinese

Author

Listed:
  • Yuanfeng Li

    (State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
    National Engineering Research Center for Protein Drugs
    National Center for Protein Sciences at Beijing)

  • Lanlan Si

    (State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
    National Engineering Research Center for Protein Drugs
    National Center for Protein Sciences at Beijing)

  • Yun Zhai

    (State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
    National Engineering Research Center for Protein Drugs
    National Center for Protein Sciences at Beijing)

  • Yanling Hu

    (Center for Genomic and Personalized Medicine, Guangxi Medical University)

  • Zhibin Hu

    (MOE Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University)

  • Jin-Xin Bei

    (State Key Laboratory of Oncology in Southern China)

  • Bobo Xie

    (State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
    National Engineering Research Center for Protein Drugs
    National Center for Protein Sciences at Beijing)

  • Qian Ren

    (State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
    National Engineering Research Center for Protein Drugs
    National Center for Protein Sciences at Beijing)

  • Pengbo Cao

    (State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
    National Engineering Research Center for Protein Drugs
    National Center for Protein Sciences at Beijing)

  • Fei Yang

    (State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
    National Engineering Research Center for Protein Drugs
    National Center for Protein Sciences at Beijing)

  • Qingfeng Song

    (Affiliated Cancer Hospital of Guangxi Medical University)

  • Zhiyu Bao

    (Affiliated Cancer Hospital of Guangxi Medical University)

  • Haitao Zhang

    (State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
    National Engineering Research Center for Protein Drugs
    National Center for Protein Sciences at Beijing)

  • Yuqing Han

    (State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
    National Engineering Research Center for Protein Drugs
    National Center for Protein Sciences at Beijing)

  • Zhifu Wang

    (State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
    National Engineering Research Center for Protein Drugs
    National Center for Protein Sciences at Beijing)

  • Xi Chen

    (State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
    National Engineering Research Center for Protein Drugs
    National Center for Protein Sciences at Beijing)

  • Xia Xia

    (State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
    National Engineering Research Center for Protein Drugs
    National Center for Protein Sciences at Beijing)

  • Hongbo Yan

    (State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
    National Engineering Research Center for Protein Drugs
    National Center for Protein Sciences at Beijing)

  • Rui Wang

    (State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
    National Engineering Research Center for Protein Drugs
    National Center for Protein Sciences at Beijing)

  • Ying Zhang

    (State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
    National Engineering Research Center for Protein Drugs
    National Center for Protein Sciences at Beijing)

  • Chengming Gao

    (State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
    National Engineering Research Center for Protein Drugs
    National Center for Protein Sciences at Beijing)

  • Jinfeng Meng

    (State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
    National Engineering Research Center for Protein Drugs
    National Center for Protein Sciences at Beijing)

  • Xinyi Tu

    (State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
    National Engineering Research Center for Protein Drugs
    National Center for Protein Sciences at Beijing)

  • Xinqiang Liang

    (Affiliated Cancer Hospital of Guangxi Medical University)

  • Ying Cui

    (Affiliated Cancer Hospital of Guangxi Medical University)

  • Ying Liu

    (National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences)

  • Xiaopan Wu

    (National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences)

  • Zhuo Li

    (Affiliated You’an Hospital, Capital University of Medical Science)

  • Huifen Wang

    (Liver Failure Treatment and Research Center)

  • Zhaoxia Li

    (the Third Affiliated Hospital, Sun Yat-sen University)

  • Bo Hu

    (the Third Affiliated Hospital, Sun Yat-sen University)

  • Minghui He

    (BGI-Shenzhen)

  • Zhibo Gao

    (BGI-Shenzhen)

  • Xiaobing Xu

    (Jinling Hospital, Clinical School of Nanjing University)

  • Hongzan Ji

    (Jinling Hospital, Clinical School of Nanjing University)

  • Chaohui Yu

    (the First Affiliated Hospital, College of Medicine, Zhejiang University)

  • Yi Sun

    (Peking University Cancer Hospital and Institute)

  • Baocai Xing

    (Peking University Cancer Hospital and Institute)

  • Xiaobo Yang

    (Center for Genomic and Personalized Medicine, Guangxi Medical University)

  • Haiying Zhang

    (Center for Genomic and Personalized Medicine, Guangxi Medical University)

  • Aihua Tan

    (Center for Genomic and Personalized Medicine, Guangxi Medical University)

  • Chunlei Wu

    (Center for Genomic and Personalized Medicine, Guangxi Medical University)

  • Weihua Jia

    (State Key Laboratory of Oncology in Southern China)

  • Shengping Li

    (State Key Laboratory of Oncology in Southern China)

  • Yi-Xin Zeng

    (State Key Laboratory of Oncology in Southern China)

  • Hongbing Shen

    (MOE Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University)

  • Fuchu He

    (State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
    National Engineering Research Center for Protein Drugs
    National Center for Protein Sciences at Beijing)

  • Zengnan Mo

    (Center for Genomic and Personalized Medicine, Guangxi Medical University)

  • Hongxing Zhang

    (State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
    National Engineering Research Center for Protein Drugs
    National Center for Protein Sciences at Beijing)

  • Gangqiao Zhou

    (State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
    National Engineering Research Center for Protein Drugs
    National Center for Protein Sciences at Beijing)

Abstract

Hepatitis B virus (HBV) infection is a common infectious disease. Here we perform a genome-wide association study (GWAS) among Chinese populations to identify novel genetic loci involved in persistent HBV infection. GWAS scan is performed in 1,251 persistently HBV infected subjects (PIs, cases) and 1,057 spontaneously recovered subjects (SRs, controls), followed by replications in four independent populations totally consisting of 3,905 PIs and 3,356 SRs. We identify a novel locus at 8p21.3 (index rs7000921, odds ratio=0.78, P=3.2 × 10−12). Furthermore, we identify significant expression quantitative trait locus associations for INTS10 gene at 8p21.3. We demonstrate that INST10 suppresses HBV replication via IRF3 in liver cells. In clinical plasma samples, we confirm that INST10 levels are significantly decreased in PIs compared with SRs, and negatively correlated with the HBV load. These findings highlight a novel antiviral gene INTS10 at 8p21.3 in the clearance of HBV infection.

Suggested Citation

  • Yuanfeng Li & Lanlan Si & Yun Zhai & Yanling Hu & Zhibin Hu & Jin-Xin Bei & Bobo Xie & Qian Ren & Pengbo Cao & Fei Yang & Qingfeng Song & Zhiyu Bao & Haitao Zhang & Yuqing Han & Zhifu Wang & Xi Chen &, 2016. "Genome-wide association study identifies 8p21.3 associated with persistent hepatitis B virus infection among Chinese," Nature Communications, Nature, vol. 7(1), pages 1-11, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11664
    DOI: 10.1038/ncomms11664
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