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Phylogenomic and biogeographic reconstruction of the Trichinella complex

Author

Listed:
  • Pasi K. Korhonen

    (Faculty of Veterinary and Agricultural Sciences, The University of Melbourne)

  • Edoardo Pozio

    (Istituto Superiore di Sanità)

  • Giuseppe La Rosa

    (Istituto Superiore di Sanità)

  • Bill C. H. Chang

    (Faculty of Veterinary and Agricultural Sciences, The University of Melbourne
    Yourgene Bioscience)

  • Anson V. Koehler

    (Faculty of Veterinary and Agricultural Sciences, The University of Melbourne)

  • Eric P. Hoberg

    (United States National Parasite Collection, Agricultural Research Service)

  • Peter R. Boag

    (Monash University)

  • Patrick Tan

    (Genome Institute of Singapore
    Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School)

  • Aaron R. Jex

    (Faculty of Veterinary and Agricultural Sciences, The University of Melbourne)

  • Andreas Hofmann

    (Faculty of Veterinary and Agricultural Sciences, The University of Melbourne
    Structural Chemistry Program, Eskitis Institute, Griffith University)

  • Paul W. Sternberg

    (Howard Hughes Medical Institute, California Institute of Technology)

  • Neil D. Young

    (Faculty of Veterinary and Agricultural Sciences, The University of Melbourne)

  • Robin B. Gasser

    (Faculty of Veterinary and Agricultural Sciences, The University of Melbourne)

Abstract

Trichinellosis is a globally important food-borne parasitic disease of humans caused by roundworms of the Trichinella complex. Extensive biological diversity is reflected in substantial ecological and genetic variability within and among Trichinella taxa, and major controversy surrounds the systematics of this complex. Here we report the sequencing and assembly of 16 draft genomes representing all 12 recognized Trichinella species and genotypes, define protein-coding gene sets and assess genetic differences among these taxa. Using thousands of shared single-copy orthologous gene sequences, we fully reconstruct, for the first time, a phylogeny and biogeography for the Trichinella complex, and show that encapsulated and non-encapsulated Trichinella taxa diverged from their most recent common ancestor ∼21 million years ago (mya), with taxon diversifications commencing ∼10−7 mya.

Suggested Citation

  • Pasi K. Korhonen & Edoardo Pozio & Giuseppe La Rosa & Bill C. H. Chang & Anson V. Koehler & Eric P. Hoberg & Peter R. Boag & Patrick Tan & Aaron R. Jex & Andreas Hofmann & Paul W. Sternberg & Neil D. , 2016. "Phylogenomic and biogeographic reconstruction of the Trichinella complex," Nature Communications, Nature, vol. 7(1), pages 1-8, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10513
    DOI: 10.1038/ncomms10513
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