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The onset of visual experience gates auditory cortex critical periods

Author

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  • Todd M. Mowery

    (Center for Neural Science, New York University, 4 Washington Place, Room 810, New York, New York 10003, USA)

  • Vibhakar C. Kotak

    (Center for Neural Science, New York University, 4 Washington Place, Room 810, New York, New York 10003, USA)

  • Dan H. Sanes

    (Center for Neural Science, New York University, 4 Washington Place, Room 810, New York, New York 10003, USA)

Abstract

Sensory systems influence one another during development and deprivation can lead to cross-modal plasticity. As auditory function begins before vision, we investigate the effect of manipulating visual experience during auditory cortex critical periods (CPs) by assessing the influence of early, normal and delayed eyelid opening on hearing loss-induced changes to membrane and inhibitory synaptic properties. Early eyelid opening closes the auditory cortex CPs precociously and dark rearing prevents this effect. In contrast, delayed eyelid opening extends the auditory cortex CPs by several additional days. The CP for recovery from hearing loss is also closed prematurely by early eyelid opening and extended by delayed eyelid opening. Furthermore, when coupled with transient hearing loss that animals normally fully recover from, very early visual experience leads to inhibitory deficits that persist into adulthood. Finally, we demonstrate a functional projection from the visual to auditory cortex that could mediate these effects.

Suggested Citation

  • Todd M. Mowery & Vibhakar C. Kotak & Dan H. Sanes, 2016. "The onset of visual experience gates auditory cortex critical periods," Nature Communications, Nature, vol. 7(1), pages 1-11, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10416
    DOI: 10.1038/ncomms10416
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