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Bioabsorbable polymer optical waveguides for deep-tissue photomedicine

Author

Listed:
  • Sedat Nizamoglu

    (Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital
    Koc University)

  • Malte C. Gather

    (Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital
    SUPA, School of Physics and Astronomy, University of St Andrews)

  • Matjaž Humar

    (Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital
    J. Stefan Institute)

  • Myunghwan Choi

    (Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital
    Global Biomedical Engineering, Sungkyunkwan University, Center for Neuroscience and Imaging Research, Institute for Basic Science, 2066, Seoburo, Jangan)

  • Seonghoon Kim

    (Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology)

  • Ki Su Kim

    (Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital)

  • Sei Kwang Hahn

    (Pohang University of Science and Technology)

  • Giuliano Scarcelli

    (Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital
    University of Maryland College Park)

  • Mark Randolph

    (Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital
    Massachusetts General Hospital)

  • Robert W. Redmond

    (Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital)

  • Seok Hyun Yun

    (Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital
    Harvard–MIT Health Sciences and Technology)

Abstract

Advances in photonics have stimulated significant progress in medicine, with many techniques now in routine clinical use. However, the finite depth of light penetration in tissue is a serious constraint to clinical utility. Here we show implantable light-delivery devices made of bio-derived or biocompatible, and biodegradable polymers. In contrast to conventional optical fibres, which must be removed from the body soon after use, the biodegradable and biocompatible waveguides may be used for long-term light delivery and need not be removed as they are gradually resorbed by the tissue. As proof of concept, we demonstrate this paradigm-shifting approach for photochemical tissue bonding (PTB). Using comb-shaped planar waveguides, we achieve a full thickness (>10 mm) wound closure of porcine skin, which represents ∼10-fold extension of the tissue area achieved with conventional PTB. The results point to a new direction in photomedicine for using light in deep tissues.

Suggested Citation

  • Sedat Nizamoglu & Malte C. Gather & Matjaž Humar & Myunghwan Choi & Seonghoon Kim & Ki Su Kim & Sei Kwang Hahn & Giuliano Scarcelli & Mark Randolph & Robert W. Redmond & Seok Hyun Yun, 2016. "Bioabsorbable polymer optical waveguides for deep-tissue photomedicine," Nature Communications, Nature, vol. 7(1), pages 1-7, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10374
    DOI: 10.1038/ncomms10374
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    Cited by:

    1. Gergely T. Iványi & Cyril Slabý & Jana Kubacková & Alena Strejčková & Zuzana Jurašeková & Zoltán Tomori & Andrej Hovan & Lóránd Kelemen & Gaszton Vizsnyiczai & Gregor Bánó, 2025. "Light-momentum-driven soft optical waveguide micro-actuators," Nature Communications, Nature, vol. 16(1), pages 1-11, December.
    2. Myeongki Cho & Jeong-Kyu Han & Jungmin Suh & Jeong Jin Kim & Jae Ryun Ryu & In Sik Min & Mingyu Sang & Selin Lim & Tae Soo Kim & Kyubeen Kim & Kyowon Kang & Kyuhyun Hwang & Kanghwan Kim & Eun-Bin Hong, 2024. "Fully bioresorbable hybrid opto-electronic neural implant system for simultaneous electrophysiological recording and optogenetic stimulation," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Kaicheng Deng & Yao Tang & Yan Xiao & Danni Zhong & Hua Zhang & Wen Fang & Liyin Shen & Zhaochuang Wang & Jiazhen Pan & Yuwen Lu & Changming Chen & Yun Gao & Qiao Jin & Lenan Zhuang & Hao Wan & Liujin, 2023. "A biodegradable, flexible photonic patch for in vivo phototherapy," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Yu Zhang & Lidian Zhang & Chengqi Zhang & Jingxia Wang & Junchao Liu & Changqing Ye & Zhichao Dong & Lei Wu & Yanlin Song, 2022. "Continuous resin refilling and hydrogen bond synergistically assisted 3D structural color printing," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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