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Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin

Author

Listed:
  • K. Long

    (MRC Centre for Regenerative Medicine, University of Edinburgh)

  • L. Moss

    (MRC Centre for Regenerative Medicine, University of Edinburgh)

  • L. Laursen

    (Aarhus University)

  • L. Boulter

    (MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, Crewe Road)

  • C. ffrench-Constant

    (MRC Centre for Regenerative Medicine, University of Edinburgh)

Abstract

Development of the cerebral cortex requires regulation of proliferation and differentiation of neural stem cells and a diverse range of progenitors. Recent work suggests a role for extracellular matrix (ECM) and the major family of ECM receptors, the integrins. Here we show that enhancing integrin beta-1 signalling, by expressing a constitutively active integrin beta-1 (CA*β1) in the embryonic chick mesencephalon, enhances neurogenesis and increases the number of mitotic cells dividing away from the ventricular surface, analogous to sub-apical progenitors in mouse. Only non-integrin-expressing neighbouring cells (lacking CA*β1) contributed to the increased neurogenesis. Transcriptome analysis reveals upregulation of Wnt7a within the CA*β1 cells and upregulation of the ECM protein Decorin in the neighbouring non-expressing cells. Experiments using inhibitors in explant models and genetic knock-downs in vivo reveal an integrin-Wnt7a-Decorin pathway that promotes proliferation and differentiation of neuroepithelial cells, and identify Decorin as a novel neurogenic factor in the central nervous system.

Suggested Citation

  • K. Long & L. Moss & L. Laursen & L. Boulter & C. ffrench-Constant, 2016. "Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin," Nature Communications, Nature, vol. 7(1), pages 1-14, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10354
    DOI: 10.1038/ncomms10354
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    Cited by:

    1. Do Hyeon Gim & Muhammad Z. K. Assir & Olivia Soper & Paul A. Fowler & Michael D. Morgan & Daniel A. Berg & Eunchai Kang, 2025. "Deciphering cell-type-and temporally specific matrisome expression signatures in human cortical development and neurodevelopmental disorders via scRNA-seq meta-analysis," Nature Communications, Nature, vol. 16(1), pages 1-19, December.

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