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KCNK5 channels mostly expressed in cochlear outer sulcus cells are indispensable for hearing

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  • Yves Cazals

    (Laboratoire de Neurosciences Intégratives et Adaptatives (UMR7260), Fédération de Recherche 3C (Cerveau, Comportement, Cognition), Aix-Marseille-Université and CNRS)

  • Michelle Bévengut

    (Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille (UMR7286), Aix-Marseille-Université and CNRS)

  • Sébastien Zanella

    (Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille (UMR7286), Aix-Marseille-Université and CNRS
    Institut de Neurosciences de la Timone (UMR7289), Aix-Marseille Université and CNRS)

  • Frédéric Brocard

    (Institut de Neurosciences de la Timone (UMR7289), Aix-Marseille Université and CNRS)

  • Jacques Barhanin

    (Laboratoire de Physio-Médecine Moléculaire (UMR7370), Université de Nice-Sophia Antipolis and CNRS
    Laboratories of Excellence, Ion Channel Science and Therapeutics)

  • Christian Gestreau

    (Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille (UMR7286), Aix-Marseille-Université and CNRS)

Abstract

In the cochlea, K+ is essential for mechano-electrical transduction. Here, we explore cochlear structure and function in mice lacking K+ channels of the two-pore domain family. A profound deafness associated with a decrease in endocochlear potential is found in adult Kcnk5−/− mice. Hearing occurs around postnatal day 19 (P19), and completely disappears 2 days later. At P19, Kcnk5−/− mice have a normal endolymphatic [K+] but a partly lowered endocochlear potential. Using Lac-Z as a gene reporter, KCNK5 is mainly found in outer sulcus Claudius’, Boettcher’s and root cells. Low levels of expression are also seen in the spiral ganglion, Reissner’s membrane and stria vascularis. Essential channels (KCNJ10 and KCNQ1) contributing to K+ secretion in stria vascularis have normal expression in Kcnk5−/− mice. Thus, KCNK5 channels are indispensable for the maintenance of hearing. Among several plausible mechanisms, we emphasize their role in K+ recycling along the outer sulcus lateral route.

Suggested Citation

  • Yves Cazals & Michelle Bévengut & Sébastien Zanella & Frédéric Brocard & Jacques Barhanin & Christian Gestreau, 2015. "KCNK5 channels mostly expressed in cochlear outer sulcus cells are indispensable for hearing," Nature Communications, Nature, vol. 6(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9780
    DOI: 10.1038/ncomms9780
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