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Cytokinin response factors regulate PIN-FORMED auxin transporters

Author

Listed:
  • Mária Šimášková

    (VIB
    Ghent University)

  • José Antonio O’Brien

    (VIB
    Ghent University)

  • Mamoona Khan

    (Institute of Science and Technology Austria (IST Austria))

  • Giel Van Noorden

    (VIB
    Ghent University)

  • Krisztina Ötvös

    (Institute of Science and Technology Austria (IST Austria))

  • Anne Vieten

    (Centre for Molecular Biology of Plants, University Tübingen)

  • Inge De Clercq

    (VIB
    Ghent University)

  • Johanna Maria Adriana Van Haperen

    (Laboratory of Biochemistry, Wageningen University)

  • Candela Cuesta

    (Institute of Science and Technology Austria (IST Austria))

  • Klára Hoyerová

    (Institute of Experimental Botany, ASCR)

  • Steffen Vanneste

    (VIB
    Ghent University)

  • Peter Marhavý

    (Institute of Science and Technology Austria (IST Austria))

  • Krzysztof Wabnik

    (Institute of Science and Technology Austria (IST Austria))

  • Frank Van Breusegem

    (VIB
    Ghent University)

  • Moritz Nowack

    (VIB
    Ghent University)

  • Angus Murphy

    (University of Maryland)

  • Jiří Friml

    (Institute of Science and Technology Austria (IST Austria))

  • Dolf Weijers

    (Laboratory of Biochemistry, Wageningen University)

  • Tom Beeckman

    (VIB
    Ghent University)

  • Eva Benková

    (Institute of Science and Technology Austria (IST Austria))

Abstract

Auxin and cytokinin are key endogenous regulators of plant development. Although cytokinin-mediated modulation of auxin distribution is a developmentally crucial hormonal interaction, its molecular basis is largely unknown. Here we show a direct regulatory link between cytokinin signalling and the auxin transport machinery uncovering a mechanistic framework for cytokinin-auxin cross-talk. We show that the CYTOKININ RESPONSE FACTORS (CRFs), transcription factors downstream of cytokinin perception, transcriptionally control genes encoding PIN-FORMED (PIN) auxin transporters at a specific PIN CYTOKININ RESPONSE ELEMENT (PCRE) domain. Removal of this cis-regulatory element effectively uncouples PIN transcription from the CRF-mediated cytokinin regulation and attenuates plant cytokinin sensitivity. We propose that CRFs represent a missing cross-talk component that fine-tunes auxin transport capacity downstream of cytokinin signalling to control plant development.

Suggested Citation

  • Mária Šimášková & José Antonio O’Brien & Mamoona Khan & Giel Van Noorden & Krisztina Ötvös & Anne Vieten & Inge De Clercq & Johanna Maria Adriana Van Haperen & Candela Cuesta & Klára Hoyerová & Steffe, 2015. "Cytokinin response factors regulate PIN-FORMED auxin transporters," Nature Communications, Nature, vol. 6(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9717
    DOI: 10.1038/ncomms9717
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