IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v6y2015i1d10.1038_ncomms9695.html
   My bibliography  Save this article

BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages

Author

Listed:
  • Alessandra Rosati

    (BIOUNIVERSA s.r.l.
    University of Salerno)

  • Anna Basile

    (BIOUNIVERSA s.r.l.
    University of Salerno)

  • Raffaella D’Auria

    (BIOUNIVERSA s.r.l.
    University of Salerno)

  • Morena d’Avenia

    (BIOUNIVERSA s.r.l.)

  • Margot De Marco

    (BIOUNIVERSA s.r.l.)

  • Antonia Falco

    (BIOUNIVERSA s.r.l.
    University of Salerno)

  • Michelina Festa

    (BIOUNIVERSA s.r.l.
    University of Salerno)

  • Luana Guerriero

    (BIOUNIVERSA s.r.l.
    University of Salerno)

  • Vittoria Iorio

    (BIOUNIVERSA s.r.l.
    University of Salerno)

  • Roberto Parente

    (BIOUNIVERSA s.r.l.)

  • Maria Pascale

    (BIOUNIVERSA s.r.l.
    University of Salerno)

  • Liberato Marzullo

    (BIOUNIVERSA s.r.l.
    University of Salerno)

  • Renato Franco

    (Pathology Unit, Istituto Nazionale Tumouri Fondazione “G. Pascale”)

  • Claudio Arra

    (Animal facility, Istituto Nazionale Tumouri Fondazione “G. Pascale”)

  • Antonio Barbieri

    (Animal facility, Istituto Nazionale Tumouri Fondazione “G. Pascale”)

  • Domenica Rea

    (Animal facility, Istituto Nazionale Tumouri Fondazione “G. Pascale”)

  • Giulio Menichini

    (Reconstructive Microsurgery, Careggi University Hospital)

  • Michael Hahne

    (Institut de Génétique Moléculaire de Montpellier, CNRS UMR5535)

  • Maarten Bijlsma

    (Laboratory for Experimental Oncology and Radiobiology, Academic Medical Center, University of Amsterdam)

  • Daniela Barcaroli

    (Orali e Biotecnologiche, University “G. d’Annunzio” di Chieti-Pescara, Centro Studi sull’Invecchiamento, CeSI-MeT)

  • Gianluca Sala

    (Orali e Biotecnologiche, University “G. d’Annunzio” di Chieti-Pescara, Centro Studi sull’Invecchiamento, CeSI-MeT)

  • Fabio Francesco di Mola

    (“S.S. Annunziata”Hospital)

  • Pierluigi di Sebastiano

    (“S.S. Annunziata”Hospital)

  • Jelena Todoric

    (Laboratory of Gene Regulation and Signal Transduction, UCSD, School of Medicine)

  • Laura Antonucci

    (Laboratory of Gene Regulation and Signal Transduction, UCSD, School of Medicine)

  • Vincent Corvest

    (CALIXAR, Bioparc, Bâtiment Laënnec)

  • Anass Jawhari

    (CALIXAR, Bioparc, Bâtiment Laënnec)

  • Matthew A Firpo

    (Huntsman Cancer Institute, University of Utah School of Medicine)

  • David A Tuveson

    (Cold Spring Harbor Laboratory)

  • Mario Capunzo

    (University of Salerno)

  • Michael Karin

    (Laboratory of Gene Regulation and Signal Transduction, UCSD, School of Medicine)

  • Vincenzo De Laurenzi

    (BIOUNIVERSA s.r.l.
    Orali e Biotecnologiche, University “G. d’Annunzio” di Chieti-Pescara, Centro Studi sull’Invecchiamento, CeSI-MeT)

  • Maria Caterina Turco

    (BIOUNIVERSA s.r.l.
    University of Salerno)

Abstract

The incidence and death rate of pancreatic ductal adenocarcinoma (PDAC) have increased in recent years, therefore the identification of novel targets for treatment is extremely important. Interactions between cancer and stromal cells are critically involved in tumour formation and development of metastasis. Here we report that PDAC cells secrete BAG3, which binds and activates macrophages, inducing their activation and the secretion of PDAC supporting factors. We also identify IFITM-2 as a BAG3 receptor and show that it signals through PI3K and the p38 MAPK pathways. Finally, we show that the use of an anti-BAG3 antibody results in reduced tumour growth and prevents metastasis formation in three different mouse models. In conclusion, we identify a paracrine loop involved in PDAC growth and metastatic spreading, and show that an anti-BAG3 antibody has therapeutic potential.

Suggested Citation

  • Alessandra Rosati & Anna Basile & Raffaella D’Auria & Morena d’Avenia & Margot De Marco & Antonia Falco & Michelina Festa & Luana Guerriero & Vittoria Iorio & Roberto Parente & Maria Pascale & Liberat, 2015. "BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages," Nature Communications, Nature, vol. 6(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9695
    DOI: 10.1038/ncomms9695
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms9695
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms9695?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9695. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.