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Genome-wide association study identifies multiple susceptibility loci for glioma

Author

Listed:
  • Ben Kinnersley

    (The Institute of Cancer Research)

  • Marianne Labussière

    (Sorbonne Universités UPMC Univ Paris 06, INSERM CNRS, U1127, UMR 7225, ICM)

  • Amy Holroyd

    (The Institute of Cancer Research)

  • Anna-Luisa Di Stefano

    (Sorbonne Universités UPMC Univ Paris 06, INSERM CNRS, U1127, UMR 7225, ICM
    Onconeurotek
    AP-HP, GH Pitié-Salpêtrière)

  • Peter Broderick

    (The Institute of Cancer Research)

  • Jayaram Vijayakrishnan

    (The Institute of Cancer Research)

  • Karima Mokhtari

    (Sorbonne Universités UPMC Univ Paris 06, INSERM CNRS, U1127, UMR 7225, ICM
    Onconeurotek
    AP-HP, GH Pitié-Salpêtrière, Laboratoire de neuropathologie R Escourolle)

  • Jean-Yves Delattre

    (Sorbonne Universités UPMC Univ Paris 06, INSERM CNRS, U1127, UMR 7225, ICM
    Onconeurotek
    AP-HP, GH Pitié-Salpêtrière)

  • Konstantinos Gousias

    (University of Bonn Medical Center)

  • Johannes Schramm

    (University of Bonn Medical Center)

  • Minouk J. Schoemaker

    (The Institute of Cancer Research)

  • Sarah J. Fleming

    (Centre for Epidemiology and Biostatistics, Faculty of Medicine and Health, University of Leeds)

  • Stefan Herms

    (Institute of Human Genetics, University of Bonn
    University of Basel)

  • Stefanie Heilmann

    (Institute of Human Genetics, University of Bonn)

  • Stefan Schreiber

    (University Clinic Schleswig-Holstein
    Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel)

  • Heinz-Erich Wichmann

    (Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health
    Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität)

  • Markus M. Nöthen

    (Institute of Human Genetics, University of Bonn)

  • Anthony Swerdlow

    (The Institute of Cancer Research
    The Institute of Cancer Research)

  • Mark Lathrop

    (AP-HP, GH Pitié-Salpêtrière, Laboratoire de neuropathologie R Escourolle
    Foundation Jean Dausset-CEPH
    Génome Québec, McGill University)

  • Matthias Simon

    (University of Bonn Medical Center)

  • Melissa Bondy

    (Dan L. Duncan Cancer Center, Baylor College of Medicine)

  • Marc Sanson

    (Sorbonne Universités UPMC Univ Paris 06, INSERM CNRS, U1127, UMR 7225, ICM
    Onconeurotek
    AP-HP, GH Pitié-Salpêtrière)

  • Richard S. Houlston

    (The Institute of Cancer Research)

Abstract

Previous genome-wide association studies (GWASs) have shown that common genetic variation contributes to the heritable risk of glioma. To identify new glioma susceptibility loci, we conducted a meta-analysis of four GWAS (totalling 4,147 cases and 7,435 controls), with imputation using 1000 Genomes and UK10K Project data as reference. After genotyping an additional 1,490 cases and 1,723 controls we identify new risk loci for glioblastoma (GBM) at 12q23.33 (rs3851634, near POLR3B, P=3.02 × 10−9) and non-GBM at 10q25.2 (rs11196067, near VTI1A, P=4.32 × 10−8), 11q23.2 (rs648044, near ZBTB16, P=6.26 × 10−11), 12q21.2 (rs12230172, P=7.53 × 10−11) and 15q24.2 (rs1801591, near ETFA, P=5.71 × 10−9). Our findings provide further insights into the genetic basis of the different glioma subtypes.

Suggested Citation

  • Ben Kinnersley & Marianne Labussière & Amy Holroyd & Anna-Luisa Di Stefano & Peter Broderick & Jayaram Vijayakrishnan & Karima Mokhtari & Jean-Yves Delattre & Konstantinos Gousias & Johannes Schramm &, 2015. "Genome-wide association study identifies multiple susceptibility loci for glioma," Nature Communications, Nature, vol. 6(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9559
    DOI: 10.1038/ncomms9559
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