IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v6y2015i1d10.1038_ncomms9437.html
   My bibliography  Save this article

Eomesodermin-expressing T-helper cells are essential for chronic neuroinflammation

Author

Listed:
  • Ben J. E. Raveney

    (National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi,Kodaira, Tokyo 187-8502, Japan)

  • Shinji Oki

    (National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi,Kodaira, Tokyo 187-8502, Japan)

  • Hirohiko Hohjoh

    (National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo 187-8502, Japan)

  • Masakazu Nakamura

    (National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi,Kodaira, Tokyo 187-8502, Japan
    Multiple Sclerosis Center, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo 187-8502, Japan)

  • Wakiro Sato

    (National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi,Kodaira, Tokyo 187-8502, Japan
    Multiple Sclerosis Center, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo 187-8502, Japan)

  • Miho Murata

    (National Center Hospital, National Center of Neurology and Psychiatry, Tokyo 187-8502, Japan)

  • Takashi Yamamura

    (National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi,Kodaira, Tokyo 187-8502, Japan
    Multiple Sclerosis Center, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo 187-8502, Japan)

Abstract

Development of acute experimental autoimmune encephalomyelitis (EAE) depends on Th17 cells expressing the nuclear factor NR4A2. However, in mice lacking NR4A2 in T cells, a late-onset disease is still inducible, despite a great reduction in acute inflammation. We here reveal that development of this late onset disease depends on cytotoxic T-cell-like CD4+ T cells expressing the T-box transcription factor Eomesodermin (Eomes). T-cell-specific deletion of the Eomes gene remarkably ameliorates the late-onset EAE. Strikingly, similar Eomes+ CD4+ T cells are increased in the peripheral blood and cerebrospinal fluid from patients in a progressive state of multiple sclerosis. Collective data indicate an involvement of granzyme B and protease-activated receptor-1 in the neuroinflammation mediated by Eomes+ CD4+ T cells.

Suggested Citation

  • Ben J. E. Raveney & Shinji Oki & Hirohiko Hohjoh & Masakazu Nakamura & Wakiro Sato & Miho Murata & Takashi Yamamura, 2015. "Eomesodermin-expressing T-helper cells are essential for chronic neuroinflammation," Nature Communications, Nature, vol. 6(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9437
    DOI: 10.1038/ncomms9437
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms9437
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms9437?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9437. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.