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Integration of carbohydrate metabolism and redox state controls dauer larva formation in Caenorhabditis elegans

Author

Listed:
  • Sider Penkov

    (Max Planck Institute of Molecular Cell Biology and Genetics)

  • Damla Kaptan

    (Max Planck Institute of Molecular Cell Biology and Genetics)

  • Cihan Erkut

    (Max Planck Institute of Molecular Cell Biology and Genetics)

  • Mihail Sarov

    (Max Planck Institute of Molecular Cell Biology and Genetics)

  • Fanny Mende

    (Max Planck Institute of Molecular Cell Biology and Genetics)

  • Teymuras V. Kurzchalia

    (Max Planck Institute of Molecular Cell Biology and Genetics)

Abstract

Under adverse conditions, Caenorhabditis elegans enters a diapause stage called the dauer larva. External cues signal the nuclear hormone receptor DAF-12, the activity of which is regulated by its ligands: dafachronic acids (DAs). DAs are synthesized from cholesterol, with the last synthesis step requiring NADPH, and their absence stimulates dauer formation. Here we show that NADPH levels determine dauer formation in a regulatory mechanism involving key carbohydrate and redox metabolic enzymes. Elevated trehalose biosynthesis diverts glucose-6-phosphate from the pentose phosphate pathway, which is the major source of cellular NADPH. This enhances dauer formation due to the decrease in the DA level. Moreover, DAF-12, in cooperation with DAF-16/FoxO, induces negative feedback of DA synthesis via activation of the trehalose-producing enzymes TPS-1/2 and inhibition of the NADPH-producing enzyme IDH-1. Thus, the dauer developmental decision is controlled by integration of the metabolic flux of carbohydrates and cellular redox potential.

Suggested Citation

  • Sider Penkov & Damla Kaptan & Cihan Erkut & Mihail Sarov & Fanny Mende & Teymuras V. Kurzchalia, 2015. "Integration of carbohydrate metabolism and redox state controls dauer larva formation in Caenorhabditis elegans," Nature Communications, Nature, vol. 6(1), pages 1-10, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9060
    DOI: 10.1038/ncomms9060
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