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Gram-scale synthesis of coordination polymer nanodots with renal clearance properties for cancer theranostic applications

Author

Listed:
  • Fuyao Liu

    (State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Xiuxia He

    (School of Life Science and Technology, Changchun University of Science and Technology)

  • Hongda Chen

    (State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences)

  • Junping Zhang

    (State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences
    School of Life Science and Technology, Changchun University of Science and Technology)

  • Huimao Zhang

    (The First Hospital of Jilin University)

  • Zhenxin Wang

    (State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences)

Abstract

An ultrasmall hydrodynamic diameter is a critical factor for the renal clearance of nanoparticles from the body within a reasonable timescale. However, the integration of diagnostic and therapeutic components into a single ultrasmall nanoparticle remains challenging. In this study, pH-activated nanodots (termed Fe-CPNDs) composed of coordination polymers were synthesized via a simple and scalable method based on coordination reactions among Fe3+, gallic acid and poly(vinylpyrrolidone) at ambient conditions. The Fe-CPNDs exhibited ultrasmall (5.3 nm) hydrodynamic diameters and electrically neutral surfaces. The Fe-CPNDs also exhibited pH-activatable magnetic resonance imaging contrast and outstanding photothermal performance. The features of Fe-CPNDs greatly increased the tumour-imaging sensitivity and facilitated renal clearance after injection in animal models in vivo. Magnetic resonance imaging-guided photothermal therapy using Fe-CPNDs completely suppressed tumour growth. These findings demonstrate that Fe-CPNDs constitute a new class of renal clearable nanomedicine for photothermal therapy and molecular imaging.

Suggested Citation

  • Fuyao Liu & Xiuxia He & Hongda Chen & Junping Zhang & Huimao Zhang & Zhenxin Wang, 2015. "Gram-scale synthesis of coordination polymer nanodots with renal clearance properties for cancer theranostic applications," Nature Communications, Nature, vol. 6(1), pages 1-9, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9003
    DOI: 10.1038/ncomms9003
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