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Selective enhancement of insulin sensitivity in the mature adipocyte is sufficient for systemic metabolic improvements

Author

Listed:
  • Thomas S. Morley

    (Touchstone Diabetes Center, The University of Texas Southwestern Medical Center)

  • Jonathan Y. Xia

    (Touchstone Diabetes Center, The University of Texas Southwestern Medical Center)

  • Philipp E. Scherer

    (Touchstone Diabetes Center, The University of Texas Southwestern Medical Center
    The University of Texas Southwestern Medical Center)

Abstract

Dysfunctional adipose tissue represents a hallmark of type 2 diabetes and systemic insulin resistance, characterized by fibrotic deposition of collagens and increased immune cell infiltration within the depots. Here we generate an inducible model of loss of function of the protein phosphatase and tensin homologue (PTEN), a phosphatase critically involved in turning off the insulin signal transduction cascade, to assess the role of enhanced insulin signalling specifically in mature adipocytes. These mice gain more weight on chow diet and short-term as well as long-term high-fat diet exposure. Despite the increase in weight, they retain enhanced insulin sensitivity, show improvements in oral glucose tolerance tests, display reduced adipose tissue inflammation and maintain elevated adiponectin levels. These improvements also lead to reduced hepatic steatosis and enhanced hepatic insulin sensitivity. Prolonging insulin action selectively in the mature adipocyte is therefore sufficient to maintain normal systemic metabolic homeostasis.

Suggested Citation

  • Thomas S. Morley & Jonathan Y. Xia & Philipp E. Scherer, 2015. "Selective enhancement of insulin sensitivity in the mature adipocyte is sufficient for systemic metabolic improvements," Nature Communications, Nature, vol. 6(1), pages 1-11, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8906
    DOI: 10.1038/ncomms8906
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    Cited by:

    1. Vissarion Efthymiou & Lianggong Ding & Miroslav Balaz & Wenfei Sun & Lucia Balazova & Leon G. Straub & Hua Dong & Eric Simon & Adhideb Ghosh & Aliki Perdikari & Svenja Keller & Umesh Ghoshdastider & C, 2023. "Inhibition of AXL receptor tyrosine kinase enhances brown adipose tissue functionality in mice," Nature Communications, Nature, vol. 14(1), pages 1-22, December.

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