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Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs

Author

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  • Vemuri B. Reddy

    (Cutaneous Biology Research Center, Massachusetts General Hospital)

  • Shuohao Sun

    (Johns Hopkins University)

  • Ehsan Azimi

    (Cutaneous Biology Research Center, Massachusetts General Hospital)

  • Sarina B. Elmariah

    (Cutaneous Biology Research Center, Massachusetts General Hospital)

  • Xinzhong Dong

    (Johns Hopkins University)

  • Ethan A. Lerner

    (Cutaneous Biology Research Center, Massachusetts General Hospital)

Abstract

Sensory neurons expressing Mas-related G-protein-coupled receptors (Mrgprs) mediate histamine-independent itch. We show that the cysteine protease cathepsin S activates MrgprC11 and evokes receptor-dependent scratching in mice. In contrast to its activation of conventional protease-activated receptors, cathepsin S-mediated activation of MrgprC11 did not involve the generation of a tethered ligand. We demonstrate further that different cysteine proteases selectively activate specific mouse and human Mrgpr family members. This expansion of our understanding by which proteases interact with G-protein-coupled receptors (GPCRs) redefines the concept of what constitutes a protease-activated receptor. The findings also implicate proteases as ligands to members of this orphan receptor family while providing new insights into how cysteine proteases contribute to itch.

Suggested Citation

  • Vemuri B. Reddy & Shuohao Sun & Ehsan Azimi & Sarina B. Elmariah & Xinzhong Dong & Ethan A. Lerner, 2015. "Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs," Nature Communications, Nature, vol. 6(1), pages 1-10, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8864
    DOI: 10.1038/ncomms8864
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