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Critical role for syndecan-4 in dendritic cell migration during development of allergic airway inflammation

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  • Tobias Polte

    (UFZ—Helmholtz Centre for Environmental Research Leipzig-Halle, Permoserstrasse 15, Leipzig 04318, Germany
    Venerology and Allergology, Leipzig University Medical Center)

  • Susanne Petzold

    (UFZ—Helmholtz Centre for Environmental Research Leipzig-Halle, Permoserstrasse 15, Leipzig 04318, Germany
    Venerology and Allergology, Leipzig University Medical Center)

  • Jessica Bertrand

    (Institute for Experimental Musculoskeletal Medicine, University Hospital Münster)

  • Nicole Schütze

    (UFZ—Helmholtz Centre for Environmental Research Leipzig-Halle, Permoserstrasse 15, Leipzig 04318, Germany
    Venerology and Allergology, Leipzig University Medical Center
    LIFE—Leipzig Research Center for Civilization Diseases, Leipzig University)

  • Denise Hinz

    (Venerology and Allergology, Leipzig University Medical Center
    LIFE—Leipzig Research Center for Civilization Diseases, Leipzig University)

  • Jan C. Simon

    (Venerology and Allergology, Leipzig University Medical Center)

  • Irina Lehmann

    (UFZ—Helmholtz Centre for Environmental Research Leipzig-Halle, Permoserstrasse 15, Leipzig 04318, Germany)

  • Frank Echtermeyer

    (Hannover Medical School)

  • Thomas Pap

    (Institute for Experimental Musculoskeletal Medicine, University Hospital Münster)

  • Marco Averbeck

    (Venerology and Allergology, Leipzig University Medical Center)

Abstract

Syndecan-4 (SDC4), expressed on dendritic cells (DCs) and activated T cells, plays a crucial role in DC motility and has been shown as a potential target for activated T-cell-driven diseases. In the present study, we investigate the role of SDC4 in the development of T-helper 2 cell-mediated allergic asthma. Using SDC4-deficient mice or an anti-SDC4 antibody we show that the absence or blocking of SDC4 signalling in ovalbumin-sensitized mice results in a reduced asthma phenotype compared with control animals. Most importantly, even established asthma is significantly decreased using the anti-SDC4 antibody. The disturbed SDC4 signalling leads to an impaired motility and directional migration of antigen-presenting DCs and therefore, to a modified sensitization leading to diminished airway inflammation. Our results demonstrate that SDC4 plays an important role in asthma induction and indicate SDC4 as possible target for therapeutic intervention in this disease.

Suggested Citation

  • Tobias Polte & Susanne Petzold & Jessica Bertrand & Nicole Schütze & Denise Hinz & Jan C. Simon & Irina Lehmann & Frank Echtermeyer & Thomas Pap & Marco Averbeck, 2015. "Critical role for syndecan-4 in dendritic cell migration during development of allergic airway inflammation," Nature Communications, Nature, vol. 6(1), pages 1-11, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8554
    DOI: 10.1038/ncomms8554
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