IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v6y2015i1d10.1038_ncomms8403.html
   My bibliography  Save this article

A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae

Author

Listed:
  • Jose Luis Ramirez

    (Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Giselle de Almeida Oliveira

    (Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
    Present address: Laboratório de Entomologia Médica, Centro de Pesquisas Rene Rachou—Fiocruz, Belo Horizonte, Brazil.)

  • Eric Calvo

    (Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Jesmond Dalli

    (Center for Experimental Therapeutics and Reperfusion Injury, Perioperative, and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School)

  • Romain A. Colas

    (Center for Experimental Therapeutics and Reperfusion Injury, Perioperative, and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School)

  • Charles N. Serhan

    (Center for Experimental Therapeutics and Reperfusion Injury, Perioperative, and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School)

  • Jose M. Ribeiro

    (Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Carolina Barillas-Mury

    (Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

Abstract

Exposure of Anopheles gambiae mosquitoes to Plasmodium infection enhances the ability of their immune system to respond to subsequent infections. However, the molecular mechanism that allows the insect innate immune system to ‘remember’ a previous encounter with a pathogen has not been established. Challenged mosquitoes constitutively release a soluble haemocyte differentiation factor into their haemolymph that, when transferred into Naive mosquitoes, also induces priming. Here we show that this factor consists of a Lipoxin/Lipocalin complex. We demonstrate that innate immune priming in mosquitoes involves a persistent increase in expression of Evokin (a lipid carrier of the lipocalin family), and in their ability to convert arachidonic acid to lipoxins, predominantly Lipoxin A4. Plasmodium ookinete midgut invasion triggers immune priming by inducing the release of a mosquito lipoxin/lipocalin complex.

Suggested Citation

  • Jose Luis Ramirez & Giselle de Almeida Oliveira & Eric Calvo & Jesmond Dalli & Romain A. Colas & Charles N. Serhan & Jose M. Ribeiro & Carolina Barillas-Mury, 2015. "A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae," Nature Communications, Nature, vol. 6(1), pages 1-7, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8403
    DOI: 10.1038/ncomms8403
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms8403
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms8403?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Feng Zhu & Hong Zheng & Suilin Chen & Kun Zhang & Xin Qin & Jingru Zhang & Taiping liu & Yongling Fan & Liting Wang & Xiaoxu Li & Jian Zhang & Wenyue Xu, 2022. "Malaria oocysts require circumsporozoite protein to evade mosquito immunity," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8403. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.