IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v6y2015i1d10.1038_ncomms8288.html
   My bibliography  Save this article

Coordination and fine motor control depend on Drosophila TRPγ

Author

Listed:
  • Bradley Akitake

    (Cellular and Developmental Biology, Neuroscience Research Institute, University of California Santa Barbara)

  • Qiuting Ren

    (The Johns Hopkins University School of Medicine)

  • Nina Boiko

    (University of Texas Health Sciences Center)

  • Jinfei Ni

    (Cellular and Developmental Biology, Neuroscience Research Institute, University of California Santa Barbara
    The Johns Hopkins University School of Medicine)

  • Takaaki Sokabe

    (Cellular and Developmental Biology, Neuroscience Research Institute, University of California Santa Barbara)

  • James D. Stockand

    (University of Texas Health Sciences Center)

  • Benjamin A. Eaton

    (University of Texas Health Sciences Center)

  • Craig Montell

    (Cellular and Developmental Biology, Neuroscience Research Institute, University of California Santa Barbara)

Abstract

Motor coordination is broadly divided into gross and fine motor control, both of which depend on proprioceptive organs. However, the channels that function specifically in fine motor control are unknown. Here we show that mutations in trpγ disrupt fine motor control while leaving gross motor proficiency intact. The mutants are unable to coordinate precise leg movements during walking, and are ineffective in traversing large gaps due to an inability in making subtle postural adaptations that are requisite for this task. TRPγ is expressed in proprioceptive organs, and is required in both neurons and glia for gap crossing. We expressed TRPγ in vitro, and found that its activity is promoted by membrane stretch. A mutation eliminating the Na+/Ca2+ exchanger suppresses the gap-crossing phenotype of trpγ flies. Our findings indicate that TRPγ contributes to fine motor control through mechanical activation in proprioceptive organs, thereby promoting Ca2+ influx, which is required for function.

Suggested Citation

  • Bradley Akitake & Qiuting Ren & Nina Boiko & Jinfei Ni & Takaaki Sokabe & James D. Stockand & Benjamin A. Eaton & Craig Montell, 2015. "Coordination and fine motor control depend on Drosophila TRPγ," Nature Communications, Nature, vol. 6(1), pages 1-13, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8288
    DOI: 10.1038/ncomms8288
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms8288
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms8288?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8288. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.