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Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules

Author

Listed:
  • Kang Liang

    (CSIRO Manufacturing Flagship)

  • Raffaele Ricco

    (CSIRO Manufacturing Flagship)

  • Cara M. Doherty

    (CSIRO Manufacturing Flagship)

  • Mark J. Styles

    (CSIRO Manufacturing Flagship)

  • Stephen Bell

    (The University of Adelaide)

  • Nigel Kirby

    (Australian Synchrotron)

  • Stephen Mudie

    (Australian Synchrotron)

  • David Haylock

    (CSIRO Manufacturing Flagship
    The Australian Regenerative Medicine Institute, Monash University)

  • Anita J. Hill

    (CSIRO Manufacturing Flagship)

  • Christian J. Doonan

    (The University of Adelaide)

  • Paolo Falcaro

    (CSIRO Manufacturing Flagship)

Abstract

Enhancing the robustness of functional biomacromolecules is a critical challenge in biotechnology, which if addressed would enhance their use in pharmaceuticals, chemical processing and biostorage. Here we report a novel method, inspired by natural biomineralization processes, which provides unprecedented protection of biomacromolecules by encapsulating them within a class of porous materials termed metal-organic frameworks. We show that proteins, enzymes and DNA rapidly induce the formation of protective metal-organic framework coatings under physiological conditions by concentrating the framework building blocks and facilitating crystallization around the biomacromolecules. The resulting biocomposite is stable under conditions that would normally decompose many biological macromolecules. For example, urease and horseradish peroxidase protected within a metal-organic framework shell are found to retain bioactivity after being treated at 80 °C and boiled in dimethylformamide (153 °C), respectively. This rapid, low-cost biomimetic mineralization process gives rise to new possibilities for the exploitation of biomacromolecules.

Suggested Citation

  • Kang Liang & Raffaele Ricco & Cara M. Doherty & Mark J. Styles & Stephen Bell & Nigel Kirby & Stephen Mudie & David Haylock & Anita J. Hill & Christian J. Doonan & Paolo Falcaro, 2015. "Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules," Nature Communications, Nature, vol. 6(1), pages 1-8, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8240
    DOI: 10.1038/ncomms8240
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    Cited by:

    1. Da Chen & Zhaoming Xia & Zhixiong Guo & Wangyan Gou & Junlong Zhao & Xuemei Zhou & Xiaohe Tan & Wenbin Li & Shoujie Zhao & Zhimin Tian & Yongquan Qu, 2023. "Bioinspired porous three-coordinated single-atom Fe nanozyme with oxidase-like activity for tumor visual identification via glutathione," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Guosheng Chen & Linjing Tong & Siming Huang & Shuyao Huang & Fang Zhu & Gangfeng Ouyang, 2022. "Hydrogen-bonded organic framework biomimetic entrapment allowing non-native biocatalytic activity in enzyme," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    3. Wei Huang & Haitao Yuan & Huangsheng Yang & Xiaomin Ma & Shuyao Huang & Hongjie Zhang & Siming Huang & Guosheng Chen & Gangfeng Ouyang, 2023. "Green synthesis of stable hybrid biocatalyst using a hydrogen-bonded, π-π-stacking supramolecular assembly for electrochemical immunosensor," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    4. Linjing Tong & Siming Huang & Yujian Shen & Suya Liu & Xiaomin Ma & Fang Zhu & Guosheng Chen & Gangfeng Ouyang, 2022. "Atomically unveiling the structure-activity relationship of biomacromolecule-metal-organic frameworks symbiotic crystal," Nature Communications, Nature, vol. 13(1), pages 1-9, December.

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