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Heparanase is a host enzyme required for herpes simplex virus-1 release from cells

Author

Listed:
  • Satvik R. Hadigal

    (Ocular Virology Laboratory, University of Illinois at Chicago)

  • Alex M. Agelidis

    (Ocular Virology Laboratory, University of Illinois at Chicago
    College of Medicine, University of Illinois at Chicago)

  • Ghadah A. Karasneh

    (Ocular Virology Laboratory, University of Illinois at Chicago
    College of Medicine, University of Illinois at Chicago)

  • Thessicar E. Antoine

    (Ocular Virology Laboratory, University of Illinois at Chicago
    College of Medicine, University of Illinois at Chicago)

  • Abraam M. Yakoub

    (Ocular Virology Laboratory, University of Illinois at Chicago
    College of Medicine, University of Illinois at Chicago)

  • Vishnu C. Ramani

    (University of Alabama at Birmingham)

  • Ali R. Djalilian

    (Ocular Virology Laboratory, University of Illinois at Chicago)

  • Ralph D. Sanderson

    (University of Alabama at Birmingham)

  • Deepak Shukla

    (Ocular Virology Laboratory, University of Illinois at Chicago
    College of Medicine, University of Illinois at Chicago)

Abstract

Herpesviruses exemplified by herpes simplex virus-1 (HSV-1) attach to cell surface heparan sulfate (HS) for entry into host cells. However, during a productive infection, the HS moieties on parent cells can trap newly exiting viral progenies and inhibit their release. Here we demonstrate that a HS-degrading enzyme of the host, heparanase (HPSE), is upregulated through NF-kB and translocated to the cell surface upon HSV-1 infection for the removal of HS to facilitate viral release. We also find a significant increase in HPSE release in vivo during infection of murine corneas and that knockdown of HPSE in vivo inhibits virus shedding. Overall, we propose that HPSE acts as a molecular switch for turning a virus-permissive ‘attachment mode’ of host cells to a virus-deterring ‘detachment mode’. Since many human viruses use HS as an attachment receptor, the HPSE-HS interplay may delineate a common mechanism for virus release.

Suggested Citation

  • Satvik R. Hadigal & Alex M. Agelidis & Ghadah A. Karasneh & Thessicar E. Antoine & Abraam M. Yakoub & Vishnu C. Ramani & Ali R. Djalilian & Ralph D. Sanderson & Deepak Shukla, 2015. "Heparanase is a host enzyme required for herpes simplex virus-1 release from cells," Nature Communications, Nature, vol. 6(1), pages 1-11, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7985
    DOI: 10.1038/ncomms7985
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    Cited by:

    1. Ieva Bagdonaite & Irina N. Marinova & Asha M. Rudjord-Levann & Emil M. H. Pallesen & Sarah L. King-Smith & Richard Karlsson & Troels B. Rømer & Yen-Hsi Chen & Rebecca L. Miller & Sigvard Olofsson & Ri, 2023. "Glycoengineered keratinocyte library reveals essential functions of specific glycans for all stages of HSV-1 infection," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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