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Nkx2.1-derived astrocytes and neurons together with Slit2 are indispensable for anterior commissure formation

Author

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  • Shilpi Minocha

    (University of Lausanne)

  • Delphine Valloton

    (University of Lausanne)

  • Athena R. Ypsilanti

    (INSERM UMR-S968, Institut de la Vision
    Sorbonne Université, UPMC University Paris 06, UMR_S 968, Institut de la Vision
    CNRS, UMR_7210)

  • Hubert Fiumelli

    (King Abdullah University of Science and Technology)

  • Elizabeth A. Allen

    (EPFL, Station 19, Batiment-SV)

  • Yuchio Yanagawa

    (Gunma University Graduate School of Medicine and Japan Science and Technology Agency, CREST)

  • Oscar Marin

    (Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández)

  • Alain Chédotal

    (INSERM UMR-S968, Institut de la Vision
    Sorbonne Université, UPMC University Paris 06, UMR_S 968, Institut de la Vision
    CNRS, UMR_7210)

  • Jean-Pierre Hornung

    (University of Lausanne)

  • Cécile Lebrand

    (University of Lausanne)

Abstract

Guidepost cells present at and surrounding the midline provide guidance cues that orient the growing axons through commissures. Here we show that the transcription factor Nkx2.1 known to control the specification of GABAergic interneurons also regulates the differentiation of astroglia and polydendrocytes within the mouse anterior commissure (AC). Nkx2.1-positive glia were found to originate from three germinal regions of the ventral telencephalon. Nkx2.1-derived glia were observed in and around the AC region by E14.5. Thereafter, a selective cell ablation strategy showed a synergistic role of Nkx2.1-derived cells, both GABAergic interneurons and astroglia, towards the proper formation of the AC. Finally, our results reveal that the Nkx2.1-regulated cells mediate AC axon guidance through the expression of the repellent cue, Slit2. These results bring forth interesting insights about the spatial and temporal origin of midline telencephalic glia, and highlight the importance of neurons and astroglia towards the formation of midline commissures.

Suggested Citation

  • Shilpi Minocha & Delphine Valloton & Athena R. Ypsilanti & Hubert Fiumelli & Elizabeth A. Allen & Yuchio Yanagawa & Oscar Marin & Alain Chédotal & Jean-Pierre Hornung & Cécile Lebrand, 2015. "Nkx2.1-derived astrocytes and neurons together with Slit2 are indispensable for anterior commissure formation," Nature Communications, Nature, vol. 6(1), pages 1-15, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7887
    DOI: 10.1038/ncomms7887
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