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Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia

Author

Listed:
  • Masahiro Miyake

    (Kyoto University Graduate School of Medicine
    Center for Genomic Medicine, Kyoto University Graduate School of Medicine)

  • Kenji Yamashiro

    (Kyoto University Graduate School of Medicine)

  • Yasuharu Tabara

    (Center for Genomic Medicine, Kyoto University Graduate School of Medicine)

  • Kenji Suda

    (Kyoto University Graduate School of Medicine)

  • Satoshi Morooka

    (Kyoto University Graduate School of Medicine)

  • Hideo Nakanishi

    (Kyoto University Graduate School of Medicine)

  • Chiea-Chuen Khor

    (Saw Swee Hock School of Public Health, National University of Singapore and National University Health System
    National University of Singapore and National University Health System
    National University of Singapore
    Genome Institute of Singapore)

  • Peng Chen

    (Saw Swee Hock School of Public Health, National University of Singapore and National University Health System)

  • Fan Qiao

    (Saw Swee Hock School of Public Health, National University of Singapore and National University Health System)

  • Isao Nakata

    (Kyoto University Graduate School of Medicine
    Center for Genomic Medicine, Kyoto University Graduate School of Medicine)

  • Yumiko Akagi-Kurashige

    (Kyoto University Graduate School of Medicine
    Center for Genomic Medicine, Kyoto University Graduate School of Medicine)

  • Norimoto Gotoh

    (Center for Genomic Medicine, Kyoto University Graduate School of Medicine)

  • Akitaka Tsujikawa

    (Kyoto University Graduate School of Medicine)

  • Akira Meguro

    (Yokohama City University Graduate School of Medicine)

  • Sentaro Kusuhara

    (Kobe University Graduate School of Medicine)

  • Ozen Polasek

    (Faculty of Medicine, University of Split)

  • Caroline Hayward

    (Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Alan F. Wright

    (Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Harry Campbell

    (Centre for Population Health Sciences, Medical School, Teviot)

  • Andrea J. Richardson

    (Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital)

  • Maria Schache

    (Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital)

  • Masaki Takeuchi

    (Yokohama City University Graduate School of Medicine
    Inflammatory Disease Section, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health)

  • David A. Mackey

    (Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital
    Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia)

  • Alex W. Hewitt

    (Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital)

  • Gabriel Cuellar

    (Statistical Genetics, QIMR Berghofer Medical Research Institute)

  • Yi Shi

    (Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People’s Hospital)

  • Luling Huang

    (Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People’s Hospital)

  • Zhenglin Yang

    (Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People’s Hospital
    School of Medicine, University of Electronic Science and Technology of China and Sichuan Provincial People’s Hospital
    Sichuan Translational Medicine Hospital, Chinese Academy of Sciences)

  • Kim Hung Leung

    (The Hong Kong Polytechnic University)

  • Patrick Y.P. Kao

    (Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University)

  • Maurice K.H. Yap

    (Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University)

  • Shea Ping Yip

    (The Hong Kong Polytechnic University)

  • Muka Moriyama

    (Tokyo Medical and Dental University)

  • Kyoko Ohno-Matsui

    (Tokyo Medical and Dental University)

  • Nobuhisa Mizuki

    (Yokohama City University Graduate School of Medicine)

  • Stuart MacGregor

    (Statistical Genetics, QIMR Berghofer Medical Research Institute)

  • Veronique Vitart

    (Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Tin Aung

    (National University of Singapore and National University Health System
    Singapore Eye Research Institute, Singapore National Eye Centre)

  • Seang-Mei Saw

    (Saw Swee Hock School of Public Health, National University of Singapore and National University Health System
    National University of Singapore and National University Health System
    Singapore Eye Research Institute, Singapore National Eye Centre)

  • E-Shyong Tai

    (Saw Swee Hock School of Public Health, National University of Singapore and National University Health System
    National University of Singapore and National University Health System
    Duke-NUS Graduate Medical School)

  • Tien Yin Wong

    (National University of Singapore and National University Health System
    Tokyo Medical and Dental University
    Singapore Eye Research Institute, Singapore National Eye Centre)

  • Ching-Yu Cheng

    (National University of Singapore and National University Health System
    Singapore Eye Research Institute, Singapore National Eye Centre
    Duke-NUS Graduate Medical School)

  • Paul N. Baird

    (Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital)

  • Ryo Yamada

    (Center for Genomic Medicine, Kyoto University Graduate School of Medicine)

  • Fumihiko Matsuda

    (Center for Genomic Medicine, Kyoto University Graduate School of Medicine)

  • Nagahisa Yoshimura

    (Kyoto University Graduate School of Medicine)

Abstract

Myopia can cause severe visual impairment. Here, we report a two-stage genome-wide association study for three myopia-related traits in 9,804 Japanese individuals, which was extended with trans-ethnic replication in 2,674 Chinese and 2,690 Caucasian individuals. We identify WNT7B as a novel susceptibility gene for axial length (rs10453441, Pmeta=3.9 × 10−13) and corneal curvature (Pmeta=2.9 × 10−40) and confirm the previously reported association between GJD2 and myopia. WNT7B significantly associates with extreme myopia in a case–control study with 1,478 Asian patients and 4,689 controls (odds ratio (OR)meta=1.13, Pmeta=0.011). We also find in a mouse model of myopia downregulation of WNT7B expression in the cornea and upregulation in the retina, suggesting its possible role in the development of myopia.

Suggested Citation

  • Masahiro Miyake & Kenji Yamashiro & Yasuharu Tabara & Kenji Suda & Satoshi Morooka & Hideo Nakanishi & Chiea-Chuen Khor & Peng Chen & Fan Qiao & Isao Nakata & Yumiko Akagi-Kurashige & Norimoto Gotoh &, 2015. "Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia," Nature Communications, Nature, vol. 6(1), pages 1-9, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7689
    DOI: 10.1038/ncomms7689
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