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A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy

Author

Listed:
  • Antoine Maruani

    (University College London)

  • Mark E.B. Smith

    (University College London)

  • Enrique Miranda

    (UCL Cancer Institute)

  • Kerry A. Chester

    (UCL Cancer Institute)

  • Vijay Chudasama

    (University College London)

  • Stephen Caddick

    (University College London)

Abstract

Although recent methods for the engineering of antibody–drug conjugates (ADCs) have gone some way to addressing the challenging issues of ADC construction, significant hurdles still remain. There is clear demand for the construction of novel ADC platforms that offer greater stability, homogeneity and flexibility. Here we describe a significant step towards a platform for next-generation antibody-based therapeutics by providing constructs that combine site-specific modification, exceptional versatility and high stability, with retention of antibody binding and structure post-modification. The relevance of the work in a biological context is also demonstrated in a cytotoxicity assay and a cell internalization study with HER2-positive and -negative breast cancer cell lines.

Suggested Citation

  • Antoine Maruani & Mark E.B. Smith & Enrique Miranda & Kerry A. Chester & Vijay Chudasama & Stephen Caddick, 2015. "A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy," Nature Communications, Nature, vol. 6(1), pages 1-9, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7645
    DOI: 10.1038/ncomms7645
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